{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Delacretaz A"],"funding":["Swiss National Science Foundation"],"pagination":["e0139155"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4604197"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(10)"],"pubmed_abstract":["Obesity development during psychotropic treatments represents a major health issue in psychiatry. Melanin-concentrating hormone receptor 2 (MCHR2) is a central receptor involved in energy homeostasis. MCHR2 shares its promoter region with MCHR2-AS1, a long antisense non-coding RNA. The aim of this study was to determine whether tagging single nucleotide polymorphisms (tSNPs) of MCHR2 and MCHR2-AS1 are associated with the body mass index (BMI) in the psychiatric and in the general population. The influence of MCHR2 and MCHR2-AS1 tSNPs on BMI was firstly investigated in a discovery psychiatric sample (n1 = 474). Positive results were tested for replication in two other psychiatric samples (n2 = 164, n3 = 178) and in two population-based samples (CoLaus, n4 = 5409; GIANT, n5 = 113809). In the"],"journal":["PloS one"],"pubmed_title":["Influence of MCHR2 and MCHR2-AS1 Genetic Polymorphisms on Body Mass Index in Psychiatric Patients and In Population-Based Subjects with Present or Past Atypical Depression."],"pmcid":["PMC4604197"],"funding_grant_id":["125759","143914"],"pubmed_authors":["Castelao E","Conus P","Quteineh L","Kutalik Z","Eap CB","Vandenberghe F","Preisig M","Saigi Morgui N","Waeber G","Aubry JM","Choong E","Magistretti P","von Gunten A","Delacretaz A","Vollenweider P","Gholam-Rezaee M"],"additional_accession":[]},"is_claimable":false,"name":"Influence of MCHR2 and MCHR2-AS1 Genetic Polymorphisms on Body Mass Index in Psychiatric Patients and In Population-Based Subjects with Present or Past Atypical Depression.","description":"Obesity development during psychotropic treatments represents a major health issue in psychiatry. Melanin-concentrating hormone receptor 2 (MCHR2) is a central receptor involved in energy homeostasis. MCHR2 shares its promoter region with MCHR2-AS1, a long antisense non-coding RNA. The aim of this study was to determine whether tagging single nucleotide polymorphisms (tSNPs) of MCHR2 and MCHR2-AS1 are associated with the body mass index (BMI) in the psychiatric and in the general population. The influence of MCHR2 and MCHR2-AS1 tSNPs on BMI was firstly investigated in a discovery psychiatric sample (n1 = 474). Positive results were tested for replication in two other psychiatric samples (n2 = 164, n3 = 178) and in two population-based samples (CoLaus, n4 = 5409; GIANT, n5 = 113809). In the","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015","modification":"2026-05-01T21:00:10.007Z","creation":"2019-03-26T22:56:10Z"},"accession":"S-EPMC4604197","cross_references":{"pubmed":["26461262"],"doi":["10.1371/journal.pone.0139155"]}}