biostudies-literatureChiang SFChang Gung University874054https://www.ebi.ac.uk/biostudies/studies/S-EPMC4606116biostudies-literatureUnknown2015<h4>Background</h4>The cancer cell secretome has been recognized as a valuable reservoir for identifying novel serum/plasma biomarkers for different cancers, including colorectal cancer (CRC). This study aimed to verify four CRC cell-secreted proteins (tumor-associated calcium signal transducer 2/trophoblast cell surface antigen 2 (TACSTD2/TROP2), tetraspanin-6 (TSPAN6), bone marrow stromal antigen 2 (BST2), and tumor necrosis factor receptor superfamily member 16 (NGFR)) as potential plasma CRC biomarkers.<h4>Methods</h4>The study population comprises 152 CRC patients and 152 controls. Target protein levels in plasma and tissue samples were assessed by ELISA and immunohistochemistry, respectively.<h4>Results</h4>Among the four candidate proteins examined by ELISA in a small sample set, onDisease markersBone Marrow Stromal Antigen 2 Is a Novel Plasma Biomarker and Prognosticator for Colorectal Carcinoma: A Secretome-Based Verification Study.PMC4606116EMRPD1D0621MOST103-2325-B-182-003MOST102-2628-B-182-013-MY3Chen JSHsieh LLYeh CYLiang YYu JSChiang SFChiang JMHsiao YCTang RKan CYTsai WSHsieh PSfalseBone Marrow Stromal Antigen 2 Is a Novel Plasma Biomarker and Prognosticator for Colorectal Carcinoma: A Secretome-Based Verification Study.<h4>Background</h4>The cancer cell secretome has been recognized as a valuable reservoir for identifying novel serum/plasma biomarkers for different cancers, including colorectal cancer (CRC). This study aimed to verify four CRC cell-secreted proteins (tumor-associated calcium signal transducer 2/trophoblast cell surface antigen 2 (TACSTD2/TROP2), tetraspanin-6 (TSPAN6), bone marrow stromal antigen 2 (BST2), and tumor necrosis factor receptor superfamily member 16 (NGFR)) as potential plasma CRC biomarkers.<h4>Methods</h4>The study population comprises 152 CRC patients and 152 controls. Target protein levels in plasma and tissue samples were assessed by ELISA and immunohistochemistry, respectively.<h4>Results</h4>Among the four candidate proteins examined by ELISA in a small sample set, on2015-01-01T00:00:00Z20152026-05-03T17:08:58.04Z2019-03-27T02:00:05ZS-EPMC46061162649493910.1155/2015/874054