{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hoseini SS"],"funding":["NHLBI NIH HHS","NCI NIH HHS"],"pagination":["1530-42"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4607259"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(7)"],"pubmed_abstract":["Co-transplantation of hematopoietic stem cells with those engineered to express leukemia-reactive T-cell receptors (TCRs) and differentiated ex vivo into precursor T cells (preTs) may reduce the risk of leukemia relapse. As expression of potentially self-(leukemia-) reactive TCRs will lead to negative selection or provoke autoimmunity upon thymic maturation, we investigated a novel concept whereby TCR expression set under the control of an inducible promoter would allow timely controlled TCR expression. After in vivo maturation and gene induction, preTs developed potent anti-leukemia effects. Engineered preTs provided protection even after repeated leukemia challenges by giving rise to effector and central memory cells. Importantly, adoptive transfer of TCR-transduced allogeneic preTs medi"],"journal":["Leukemia"],"pubmed_title":["Inducible T-cell receptor expression in precursor T cells for leukemia control."],"pmcid":["PMC4607259"],"funding_grant_id":["P01 CA065493","R01 CA72669","R01 CA072669","R01 HL056067"],"pubmed_authors":["Heinz N","Herbst J","Vignali DA","Wedekind D","Baumann R","Blazar BR","van den Brink MR","Schambach A","Schiedlmeier B","Hapke M","Hoseini SS","Sauer MG"],"additional_accession":[]},"is_claimable":false,"name":"Inducible T-cell receptor expression in precursor T cells for leukemia control.","description":"Co-transplantation of hematopoietic stem cells with those engineered to express leukemia-reactive T-cell receptors (TCRs) and differentiated ex vivo into precursor T cells (preTs) may reduce the risk of leukemia relapse. As expression of potentially self-(leukemia-) reactive TCRs will lead to negative selection or provoke autoimmunity upon thymic maturation, we investigated a novel concept whereby TCR expression set under the control of an inducible promoter would allow timely controlled TCR expression. After in vivo maturation and gene induction, preTs developed potent anti-leukemia effects. Engineered preTs provided protection even after repeated leukemia challenges by giving rise to effector and central memory cells. Importantly, adoptive transfer of TCR-transduced allogeneic preTs medi","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jul","modification":"2025-04-04T01:29:09.685Z","creation":"2019-03-27T02:00:08Z"},"accession":"S-EPMC4607259","cross_references":{"pubmed":["25652739"],"doi":["10.1038/leu.2015.20"]}}