biostudies-literature00440Unknown10(10)Kirillova YNew polyanionic modifications of polyamide nucleic acid mimics were obtained. Thymine decamers were synthesized from respective chiral α- and γ-monomers, and their enantiomeric purity was assessed. Here, we present the decamer synthesis, purification and characterization by MALDI-TOF mass spectrometry and an investigation of the hybridization properties of the decamers. We show that the modified γ-S-carboxyethyl-T10 PNA forms a stable triplex with polyadenine DNA.PloS onee0140468https://www.ebi.ac.uk/biostudies/studies/S-EPMC4607454biostudies-literaturePolyanionic Carboxyethyl Peptide Nucleic Acids (ce-PNAs): Synthesis and DNA Binding.PMC4607454Pozmogova GBoyarskaya NSmirnov IDezhenkov AEsipov DKirillova YVarizhuk ATankevich MProkhorov IEremin S44falsePolyanionic Carboxyethyl Peptide Nucleic Acids (ce-PNAs): Synthesis and DNA Binding.New polyanionic modifications of polyamide nucleic acid mimics were obtained. Thymine decamers were synthesized from respective chiral α- and γ-monomers, and their enantiomeric purity was assessed. Here, we present the decamer synthesis, purification and characterization by MALDI-TOF mass spectrometry and an investigation of the hybridization properties of the decamers. We show that the modified γ-S-carboxyethyl-T10 PNA forms a stable triplex with polyadenine DNA.2015-01-01T00:00:00Z20152024-11-06T03:48:31.573Z2019-03-26T23:25:43ZS-EPMC46074542646933710.1371/journal.pone.0140468