{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Predazzi IM"],"funding":["NIA NIH HHS","NHLBI NIH HHS","NIGMS NIH HHS"],"pagination":["e001951"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4608079"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(7)"],"pubmed_abstract":["Background
Plasma lipid levels are highly heritable traits, but known genetic loci can only explain a small portion of their heritability.Methods and results
In this study, we analyzed the role of parental levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TGs) in explaining the values of the corresponding traits in adult offspring. We also evaluated the contribution of nongenetic factors that influence lipid traits (age, body mass index, smoking, medications, and menopause) alone and in combination with variability at the genetic loci known to associate with TC, LDL-C, HDL-C, and TG levels. We performed comparisons among different sex-specific regression models in 416 families from"],"journal":["Journal of the American Heart Association"],"pubmed_title":["Sex-Specific Parental Effects on Offspring Lipid Levels."],"pmcid":["PMC4608079"],"funding_grant_id":["2T32HL007751‐16A2","N01‐AG‐1‐2109","P01 HL116263","2R01HL057986‐15A1","P20GM103534","5R01HL106845‐03","HL116263","T32 GM007347"],"pubmed_authors":["Bush WS","Bartlett J","Sobota RS","Schlessinger D","Williams SM","Lilley JS","Sanna S","Fazio S","Linton MF","Predazzi IM","Cucca F"],"additional_accession":[]},"is_claimable":false,"name":"Sex-Specific Parental Effects on Offspring Lipid Levels.","description":"Background
Plasma lipid levels are highly heritable traits, but known genetic loci can only explain a small portion of their heritability.Methods and results
In this study, we analyzed the role of parental levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TGs) in explaining the values of the corresponding traits in adult offspring. We also evaluated the contribution of nongenetic factors that influence lipid traits (age, body mass index, smoking, medications, and menopause) alone and in combination with variability at the genetic loci known to associate with TC, LDL-C, HDL-C, and TG levels. We performed comparisons among different sex-specific regression models in 416 families from","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jun","modification":"2026-04-18T07:37:45.233Z","creation":"2019-03-27T02:00:10Z"},"accession":"S-EPMC4608079","cross_references":{"pubmed":["26126546"],"doi":["10.1161/JAHA.115.001951"]}}