{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Touchette MH"],"funding":["U.S. Department of Energy","U.S. Department of Health and Human Services","NCRR NIH HHS","NCI NIH HHS","NIGMS NIH HHS","Stony Wold-Herbert Fund","National Science Foundation"],"pagination":["5457-68"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4609546"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["54(35)"],"pubmed_abstract":["Although they are classified as Gram-positive bacteria, Corynebacterineae possess an asymmetric outer membrane that imparts structural and thereby physiological similarity to more distantly related Gram-negative bacteria. Like lipopolysaccharide in Gram-negative bacteria, lipids in the outer membrane of Corynebacterineae have been associated with the virulence of pathogenic species such as Mycobacterium tuberculosis (Mtb). For example, Mtb strains that lack long, branched-chain alkyl esters known as dimycocerosates (DIMs) are significantly attenuated in model infections. The resultant interest in the biosynthetic pathway of these unusual virulence factors has led to the elucidation of many of the steps leading to the final esterification of the alkyl β-diol, phthiocerol, with branched-chai"],"journal":["Biochemistry"],"pubmed_title":["Diacyltransferase Activity and Chain Length Specificity of Mycobacterium tuberculosis PapA5 in the Synthesis of Alkyl β-Diol Lipids."],"pmcid":["PMC4609546"],"funding_grant_id":["CA58530","T32 GM092714","CHE-1058439","GM102864","S10 RR021008","R01 GM102864","1 S10 RR023680-1","S10 RR023680","R01 CA058530"],"pubmed_authors":["Bommineni GR","Martin DW","Seeliger JC","Sampson NS","Delle Bovi RJ","Tonge PJ","Metz TO","Nicora CD","Touchette MH","Shukla AK","Miller WT","Kyle JE","Gadbery JE"],"additional_accession":[]},"is_claimable":false,"name":"Diacyltransferase Activity and Chain Length Specificity of Mycobacterium tuberculosis PapA5 in the Synthesis of Alkyl β-Diol Lipids.","description":"Although they are classified as Gram-positive bacteria, Corynebacterineae possess an asymmetric outer membrane that imparts structural and thereby physiological similarity to more distantly related Gram-negative bacteria. Like lipopolysaccharide in Gram-negative bacteria, lipids in the outer membrane of Corynebacterineae have been associated with the virulence of pathogenic species such as Mycobacterium tuberculosis (Mtb). For example, Mtb strains that lack long, branched-chain alkyl esters known as dimycocerosates (DIMs) are significantly attenuated in model infections. The resultant interest in the biosynthetic pathway of these unusual virulence factors has led to the elucidation of many of the steps leading to the final esterification of the alkyl β-diol, phthiocerol, with branched-chai","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Sep","modification":"2026-05-04T16:31:52.275Z","creation":"2026-04-07T20:39:40.027Z"},"accession":"S-EPMC4609546","cross_references":{"pubmed":["26271001"],"doi":["10.1021/acs.biochem.5b00455"]}}