{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hatzistergos KE"],"funding":["HHS | National Institutes of Health","Deutsche Forschungsgemeinschaft","NHLBI NIH HHS","PHS HHS"],"pagination":["13051-6"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4620867"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["112(42)"],"pubmed_abstract":["The degree to which cKit-expressing progenitors generate cardiomyocytes in the heart is controversial. Genetic fate-mapping studies suggest minimal contribution; however, whether or not minimal contribution reflects minimal cardiomyogenic capacity is unclear because the embryonic origin and role in cardiogenesis of these progenitors remain elusive. Using high-resolution genetic fate-mapping approaches with cKit(CreERT2/+) and Wnt1::Flpe mouse lines, we show that cKit delineates cardiac neural crest progenitors (CNC(kit)). CNC(kit) possess full cardiomyogenic capacity and contribute to all CNC derivatives, including cardiac conduction system cells. Furthermore, by modeling cardiogenesis in cKit(CreERT2)-induced pluripotent stem cells, we show that, paradoxically, the cardiogenic fate of CNC"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["cKit+ cardiac progenitors of neural crest origin."],"pmcid":["PMC4620867"],"funding_grant_id":["5UM HL113460","R01 HL094849","R01 HL110737","R01 HL107110","SA 1374/1-3","5UMHL113460","R01 HL084275","UM1 HL113460"],"pubmed_authors":["Hatzistergos KE","White IA","Balkan W","Seidler B","Dymecki SM","Mai JJ","Schally AV","Takeuchi LM","Hare JM","Kanashiro-Takeuchi RM","Saur D"],"additional_accession":[]},"is_claimable":false,"name":"cKit+ cardiac progenitors of neural crest origin.","description":"The degree to which cKit-expressing progenitors generate cardiomyocytes in the heart is controversial. Genetic fate-mapping studies suggest minimal contribution; however, whether or not minimal contribution reflects minimal cardiomyogenic capacity is unclear because the embryonic origin and role in cardiogenesis of these progenitors remain elusive. Using high-resolution genetic fate-mapping approaches with cKit(CreERT2/+) and Wnt1::Flpe mouse lines, we show that cKit delineates cardiac neural crest progenitors (CNC(kit)). CNC(kit) possess full cardiomyogenic capacity and contribute to all CNC derivatives, including cardiac conduction system cells. Furthermore, by modeling cardiogenesis in cKit(CreERT2)-induced pluripotent stem cells, we show that, paradoxically, the cardiogenic fate of CNC","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Oct","modification":"2025-04-22T21:23:41.132Z","creation":"2019-03-27T02:00:47Z"},"accession":"S-EPMC4620867","cross_references":{"pubmed":["26438843"],"doi":["10.1073/pnas.1517201112"]}}