biostudies-literatureBeachler DCNational Institute of Allergy and Infectious DiseaseNIDCR NIH HHSNCATS NIH HHSNIAID NIH HHSNational Cancer InstituteNCI NIH HHSNational Institute of Dental and Craniofacial ResearchPHS HHS1588-91https://www.ebi.ac.uk/biostudies/studies/S-EPMC4621250biostudies-literatureUnknown212(10)The association between oral human papillomavirus 16 (HPV16) DNA load and infection clearance was evaluated among 88 individuals with oral HPV16 infection who were identified within a prospective cohort of 1470 HIV-infected and uninfected individuals. Oral rinse specimens were collected semiannually for up to 5 years. The oral HPV16 load at the time of the first positive test result was significantly associated with the time to clearance of infection (continuous P trends <.01). Notably, clearance rates by 24 months were 41% and 94% in the highest and lowest HPV16 load tertiles (P = .03), respectively. High oral HPV16 load warrants consideration as a biomarker for infection persistence, the presumed precursor of HPV16-associated oropharyngeal cancer.The Journal of infectious diseasesHigh Oral Human Papillomavirus Type 16 Load Predicts Long-term Persistence in Individuals With or at Risk for HIV Infection.PMC4621250T32 CA CA009314T32 CA009314U01-AI35039U01-AI-031834U01-A1-35043U01-AI-042590U01 AI031834UL1 TR000424UM1 AI035043U01 AI035004U01 AI034993UL1-TR000424U01 AI035039R01 DE021395U01-AI-034993U01 AI035041U01 AI035042UM1-AI35043U01 AI042590U01-AI35042U01-AI35041Beachler DCGuo YMargolick JBJacobson LPXiao WSugar EAD'Souza GReddy SGillison MLWeber KMCranston RDMinkoff HStrickler HDWiley DJBurk RDfalseHigh Oral Human Papillomavirus Type 16 Load Predicts Long-term Persistence in Individuals With or at Risk for HIV Infection.The association between oral human papillomavirus 16 (HPV16) DNA load and infection clearance was evaluated among 88 individuals with oral HPV16 infection who were identified within a prospective cohort of 1470 HIV-infected and uninfected individuals. Oral rinse specimens were collected semiannually for up to 5 years. The oral HPV16 load at the time of the first positive test result was significantly associated with the time to clearance of infection (continuous P trends <.01). Notably, clearance rates by 24 months were 41% and 94% in the highest and lowest HPV16 load tertiles (P = .03), respectively. High oral HPV16 load warrants consideration as a biomarker for infection persistence, the presumed precursor of HPV16-associated oropharyngeal cancer.2015-01-01T00:00:00Z2015 Nov2025-04-22T21:21:15.035Z2019-03-27T02:00:48ZS-EPMC46212502595404910.1093/infdis/jiv273