biostudies-literatureLiu DNational Natural Science Foundation of China950-60https://www.ebi.ac.uk/biostudies/studies/S-EPMC4621448biostudies-literatureUnknown8(6)Composting is an appropriate management alternative for municipal solid waste; however, our knowledge about the microbial regulation of this process is still scare. We employed metaproteomics to elucidate the main biodegradation pathways in municipal solid waste composting system across the main phases in a large-scale composting plant. The investigation of microbial succession revealed that Bacillales, Actinobacteria and Saccharomyces increased significantly with respect to abundance in composting process. The key microbiologic population for cellulose degradation in different composting stages was different. Fungi were found to be the main producers of cellulase in earlier phase. However, the cellulolytic fungal communities were gradually replaced by a purely bacterial one in active phasMicrobial biotechnologyMetaproteomics reveals major microbial players and their biodegradation functions in a large-scale aerobic composting plant.PMC462144851178090Song CXi BLiu DWei ZLi MZhao YZhu CfalseMetaproteomics reveals major microbial players and their biodegradation functions in a large-scale aerobic composting plant.Composting is an appropriate management alternative for municipal solid waste; however, our knowledge about the microbial regulation of this process is still scare. We employed metaproteomics to elucidate the main biodegradation pathways in municipal solid waste composting system across the main phases in a large-scale composting plant. The investigation of microbial succession revealed that Bacillales, Actinobacteria and Saccharomyces increased significantly with respect to abundance in composting process. The key microbiologic population for cellulose degradation in different composting stages was different. Fungi were found to be the main producers of cellulase in earlier phase. However, the cellulolytic fungal communities were gradually replaced by a purely bacterial one in active phas2015-01-01T00:00:00Z2015 Nov2026-04-07T16:36:09.67Z2019-03-27T02:00:48ZS-EPMC46214482598941710.1111/1751-7915.12290