{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bohr T"],"funding":["NIGMS NIH HHS","NIH HHS"],"pagination":["233-42"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4621841"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["211(2)"],"pubmed_abstract":["Homologue synapsis is required for meiotic chromosome segregation, but how synapsis is initiated between chromosomes is poorly understood. In Caenorhabditis elegans, synapsis and a checkpoint that monitors synapsis depend on pairing centers (PCs), cis-acting loci that interact with nuclear envelope proteins, such as SUN-1, to access cytoplasmic microtubules. Here, we report that spindle assembly checkpoint (SAC) components MAD-1, MAD-2, and BUB-3 are required to negatively regulate synapsis and promote the synapsis checkpoint response. Both of these roles are independent of a conserved component of the anaphase-promoting complex, indicating a unique role for these proteins in meiotic prophase. MAD-1 and MAD-2 localize to the periphery of meiotic nuclei and interact with SUN-1, suggesting a"],"journal":["The Journal of cell biology"],"pubmed_title":["Spindle assembly checkpoint proteins regulate and monitor meiotic synapsis in C. elegans."],"pmcid":["PMC4621841"],"funding_grant_id":["R01GM097144","T32 GM008646","R01 GM097144","P40 OD010440","T32GM008646","R25 GM058903"],"pubmed_authors":["Bhalla N","Bohr T","Klee E","Nelson CR"],"additional_accession":[]},"is_claimable":false,"name":"Spindle assembly checkpoint proteins regulate and monitor meiotic synapsis in C. elegans.","description":"Homologue synapsis is required for meiotic chromosome segregation, but how synapsis is initiated between chromosomes is poorly understood. In Caenorhabditis elegans, synapsis and a checkpoint that monitors synapsis depend on pairing centers (PCs), cis-acting loci that interact with nuclear envelope proteins, such as SUN-1, to access cytoplasmic microtubules. Here, we report that spindle assembly checkpoint (SAC) components MAD-1, MAD-2, and BUB-3 are required to negatively regulate synapsis and promote the synapsis checkpoint response. Both of these roles are independent of a conserved component of the anaphase-promoting complex, indicating a unique role for these proteins in meiotic prophase. MAD-1 and MAD-2 localize to the periphery of meiotic nuclei and interact with SUN-1, suggesting a","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Oct","modification":"2025-04-06T19:45:20.461Z","creation":"2019-03-27T02:00:49Z"},"accession":"S-EPMC4621841","cross_references":{"pubmed":["26483555"],"doi":["10.1083/jcb.201409035"]}}