biostudies-literatureUnknown8Qi Y<h4>Background</h4>Synovial sarcoma (SS) is one of the most aggressive soft-tissue sarcomas and is noted for late local recurrence and metastasis. It is of uncertain histological origin and exhibits a biphasic histopathological form involving both the mesenchyme and epithelium. Thus, its diagnosis and therapy remain a huge challenge for clinicians and pathologists. This study aimed to determine whether differential morphological-associated genomic changes could aid in ascertaining the histogenesis of SS and to determine whether these sarcomas showed some specific mutated genes between epithelial and spindle cells that would promote tumor invasion and metastasis.<h4>Methods</h4>We conducted a comprehensive genomic analysis of mesenchymal and epithelial components in 12 formalin-fixed paraffBMC medical genomics69https://www.ebi.ac.uk/biostudies/studies/S-EPMC4621929biostudies-literatureIdentification of potential mutations and genomic alterations in the epithelial and spindle cell components of biphasic synovial sarcomas using a human exome SNP chip.PMC4621929Zou HLiu CXYuan XLWang NPang LJZhang WJZhang JQi YLi FHu JMZhao JfalseIdentification of potential mutations and genomic alterations in the epithelial and spindle cell components of biphasic synovial sarcomas using a human exome SNP chip.<h4>Background</h4>Synovial sarcoma (SS) is one of the most aggressive soft-tissue sarcomas and is noted for late local recurrence and metastasis. It is of uncertain histological origin and exhibits a biphasic histopathological form involving both the mesenchyme and epithelium. Thus, its diagnosis and therapy remain a huge challenge for clinicians and pathologists. This study aimed to determine whether differential morphological-associated genomic changes could aid in ascertaining the histogenesis of SS and to determine whether these sarcomas showed some specific mutated genes between epithelial and spindle cells that would promote tumor invasion and metastasis.<h4>Methods</h4>We conducted a comprehensive genomic analysis of mesenchymal and epithelial components in 12 formalin-fixed paraff2015-01-01T00:00:00Z2015 Oct2026-06-10T08:51:18.08Z2019-03-27T02:00:50ZS-EPMC46219292650354510.1186/s12920-015-0144-7