{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cortina-Ceballos B"],"funding":["Cancer Research UK"],"pagination":["516-24"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4622655"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(3)"],"pubmed_abstract":["The B cell antigen receptor repertoire is highly diverse and constantly modified by clonal selection. High-throughput DNA sequencing (HTS) of the lymphocyte repertoire (Rep-Seq) represents a promising technology to explore such diversity ex-vivo and assist in the identification of antigen-specific antibodies based on molecular signatures of clonal selection. Therefore, integrative tools for repertoire reconstruction and analysis from antibody sequences are needed. We developed ImmunediveRity, a stand-alone pipeline primarily based in R programming for the integral analysis of B cell repertoire data generated by HTS. The pipeline integrates GNU software and in house scripts to perform quality filtering, sequencing noise correction and repertoire reconstruction based on V, D and J segment as"],"journal":["mAbs"],"pubmed_title":["Reconstructing and mining the B cell repertoire with ImmunediveRsity."],"pmcid":["PMC4622655"],"funding_grant_id":["14356"],"pubmed_authors":["Godoy-Lozano EE","Romero G","Martinez-Barnetche J","Cortina-Ceballos B","Velasco-Herrera Mdel C","Velazquez-Ramirez D","Vargas-Chavez C","Aguilar-Salgado A","Moreno J","Samano-Sanchez H","Tellez-Sosa J"],"additional_accession":[]},"is_claimable":false,"name":"Reconstructing and mining the B cell repertoire with ImmunediveRsity.","description":"The B cell antigen receptor repertoire is highly diverse and constantly modified by clonal selection. High-throughput DNA sequencing (HTS) of the lymphocyte repertoire (Rep-Seq) represents a promising technology to explore such diversity ex-vivo and assist in the identification of antigen-specific antibodies based on molecular signatures of clonal selection. Therefore, integrative tools for repertoire reconstruction and analysis from antibody sequences are needed. We developed ImmunediveRity, a stand-alone pipeline primarily based in R programming for the integral analysis of B cell repertoire data generated by HTS. The pipeline integrates GNU software and in house scripts to perform quality filtering, sequencing noise correction and repertoire reconstruction based on V, D and J segment as","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015","modification":"2026-05-05T05:34:03.992Z","creation":"2019-03-27T02:00:52Z"},"accession":"S-EPMC4622655","cross_references":{"pubmed":["25875140"],"doi":["10.1080/19420862.2015.1026502"]}}