{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sengupta D"],"funding":["NCI NIH HHS","NIGMS NIH HHS"],"pagination":["460-6"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4622756"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(6)"],"pubmed_abstract":["Pathologic c-Myc expression is frequently detected in human cancers, including Merkel cell carcinoma (MCC), an aggressive skin cancer with no cure for metastatic disease. Bromodomain protein 4 (BRD4) regulates gene transcription by binding to acetylated histone H3 lysine 27 (H3K27Ac) on the chromatin. Super-enhancers of transcription are identified by enrichment of H3K27Ac. BET inhibitor JQ1 disrupts BRD4 association with super-enhancers, downregulates proto-oncogenes, such as c-Myc, and displays antitumor activity in preclinical animal models of human cancers. Here we show that an enhancer proximal to the c-Myc promoter is enriched in H3K27Ac and associated with high occupancy of BRD4, and coincides with a putative c-Myc super-enhancer in MCC cells. This observation is mirrored in tumors "],"journal":["Epigenetics"],"pubmed_title":["Disruption of BRD4 at H3K27Ac-enriched enhancer region correlates with decreased c-Myc expression in Merkel cell carcinoma."],"pmcid":["PMC4622756"],"funding_grant_id":["P30GM103450","R33CA173264","P30 GM103450","R01GM106024","P20GM103429"],"pubmed_authors":["Vural E","Kannan A","Kern M","Moreno MA","Stack B","Gao L","Suen JY","Sengupta D","Tackett AJ"],"additional_accession":[]},"is_claimable":false,"name":"Disruption of BRD4 at H3K27Ac-enriched enhancer region correlates with decreased c-Myc expression in Merkel cell carcinoma.","description":"Pathologic c-Myc expression is frequently detected in human cancers, including Merkel cell carcinoma (MCC), an aggressive skin cancer with no cure for metastatic disease. Bromodomain protein 4 (BRD4) regulates gene transcription by binding to acetylated histone H3 lysine 27 (H3K27Ac) on the chromatin. Super-enhancers of transcription are identified by enrichment of H3K27Ac. BET inhibitor JQ1 disrupts BRD4 association with super-enhancers, downregulates proto-oncogenes, such as c-Myc, and displays antitumor activity in preclinical animal models of human cancers. Here we show that an enhancer proximal to the c-Myc promoter is enriched in H3K27Ac and associated with high occupancy of BRD4, and coincides with a putative c-Myc super-enhancer in MCC cells. This observation is mirrored in tumors ","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015","modification":"2026-04-07T23:02:59.321Z","creation":"2019-03-27T02:00:52Z"},"accession":"S-EPMC4622756","cross_references":{"pubmed":["25941994"],"doi":["10.1080/15592294.2015.1034416"]}}