{"database":"biostudies-literature","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":47,"searchCount":0},"additional":{"omics_type":["Unknown"],"volume":["109(2)"],"submitter":["Zaritsky A"],"pubmed_abstract":["Analysis of recently published high-throughput measurements of wild-type Escherichia coli cells growing at a wide range of rates demonstrates that cell width W, which is constant at any particular growth rate, is related (with a CV = 2.4%) to the level of nucleoid complexity, expressed as the amount of DNA in genome equivalents that is associated with chromosome terminus (G/terC). The relatively constant (CV = 7.3%) aspect ratio of newborn cells (Lb/W) in populations growing at different rates indicates existence of cell-shape homeostasis. Enlarged W of thymine-limited thyA mutants growing at identical rates support the hypothesis that nucleoid complexity actively affects W. Nucleoid dynamics is proposed to transmit a primary signal to the peptidoglycan-synthesizing system through the transertion mechanism, i.e., coupled transcription/translation of genes encoding membrane proteins and inserting these proteins into the membrane."],"journal":["Biophysical journal"],"pagination":["178-81"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4623199"],"repository":["biostudies-literature"],"pubmed_title":["Cell-shape homeostasis in Escherichia coli is driven by growth, division, and nucleoid complexity."],"pmcid":["PMC4623199"],"pubmed_authors":["Zaritsky A"],"view_count":["47"],"additional_accession":[]},"is_claimable":false,"name":"Cell-shape homeostasis in Escherichia coli is driven by growth, division, and nucleoid complexity.","description":"Analysis of recently published high-throughput measurements of wild-type Escherichia coli cells growing at a wide range of rates demonstrates that cell width W, which is constant at any particular growth rate, is related (with a CV = 2.4%) to the level of nucleoid complexity, expressed as the amount of DNA in genome equivalents that is associated with chromosome terminus (G/terC). The relatively constant (CV = 7.3%) aspect ratio of newborn cells (Lb/W) in populations growing at different rates indicates existence of cell-shape homeostasis. Enlarged W of thymine-limited thyA mutants growing at identical rates support the hypothesis that nucleoid complexity actively affects W. Nucleoid dynamics is proposed to transmit a primary signal to the peptidoglycan-synthesizing system through the transertion mechanism, i.e., coupled transcription/translation of genes encoding membrane proteins and inserting these proteins into the membrane.","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jul","modification":"2020-10-02T07:37:45Z","creation":"2019-03-27T02:00:54Z"},"accession":"S-EPMC4623199","cross_references":{"pubmed":["26200854"],"doi":["10.1016/j.bpj.2015.06.026"]}}