{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hill A"],"funding":["Howard Hughes Medical Institute","NIAMS NIH HHS","NIH"],"pagination":["3070-81"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4626303"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["67(11)"],"pubmed_abstract":["<h4>Objective</h4>Congenital deficiency of the principal boundary lubricant in cartilage (i.e., lubricin, encoded by the gene PRG4) increases joint friction and causes progressive joint failure. This study was undertaken to determine whether restoring lubricin expression in a mouse model would prevent, delay, or reverse the disease process caused by congenital deficiency.<h4>Methods</h4>Using genetically engineered lubricin-deficient mice, we restored gene function before conception or at ages 3 weeks, 2 months, or 6 months after birth. The effect of restoring gene function (i.e., expression of lubricin) on the tibiofemoral patellar joints of mice was evaluated histologically and by ex vivo biomechanical testing.<h4>Results</h4>Restoring gene function in mice prior to conception prevented "],"journal":["Arthritis & rheumatology (Hoboken, N.J.)"],"pubmed_title":["Lubricin restoration in a mouse model of congenital deficiency."],"pmcid":["PMC4626303"],"funding_grant_id":["R01 AR050180","AR-050180"],"pubmed_authors":["Lessard SG","Allen JM","Hill A","Zhang LX","Cui Y","Ayturk UM","Zurakowski D","Hann S","Waller KA","Smits P","Warman ML","Jay GD"],"additional_accession":[]},"is_claimable":false,"name":"Lubricin restoration in a mouse model of congenital deficiency.","description":"<h4>Objective</h4>Congenital deficiency of the principal boundary lubricant in cartilage (i.e., lubricin, encoded by the gene PRG4) increases joint friction and causes progressive joint failure. This study was undertaken to determine whether restoring lubricin expression in a mouse model would prevent, delay, or reverse the disease process caused by congenital deficiency.<h4>Methods</h4>Using genetically engineered lubricin-deficient mice, we restored gene function before conception or at ages 3 weeks, 2 months, or 6 months after birth. The effect of restoring gene function (i.e., expression of lubricin) on the tibiofemoral patellar joints of mice was evaluated histologically and by ex vivo biomechanical testing.<h4>Results</h4>Restoring gene function in mice prior to conception prevented ","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Nov","modification":"2025-04-04T19:07:15.725Z","creation":"2019-03-27T02:01:02Z"},"accession":"S-EPMC4626303","cross_references":{"pubmed":["26216721"],"doi":["10.1002/art.39276"]}}