biostudies-literatureTong HNCRR NIH HHS1173-9https://www.ebi.ac.uk/biostudies/studies/S-EPMC4629741biostudies-literatureUnknown123(11)<h4>Background</h4>Exposure to ambient particulate matter (PM) induces endothelial dysfunction, a risk factor for cardiovascular disease. Olive oil (OO) and fish oil (FO) supplements have beneficial effects on endothelial function.<h4>Objective</h4>In this study we evaluated the potential efficacy of OO and FO in mitigating endothelial dysfunction and disruption of hemostasis caused by exposure to particulate matter (PM).<h4>Methods and results</h4>Forty-two participants (58 ± 1 years of age) received either 3 g/day of OO or FO, or no supplements (naive) for 4 weeks prior to undergoing 2-hr exposures to filtered air and concentrated ambient particulate matter (CAP; mean, 253 ± 16 μg/m3). Endothelial function was assessed by flow-mediated dilation (FMD) of the brachial artery preexposure, iEnvironmental health perspectivesDietary Supplementation with Olive Oil or Fish Oil and Vascular Effects of Concentrated Ambient Particulate Matter Exposure in Human Volunteers.PMC4629741RR00046M01 RR000046Bromberg PACascio WEBerntsen JDiaz-Sanchez DCase MWHinderliter ALRappold AGBassett MSamet JMCaughey MTong HMontilla TDevlin RBfalseDietary Supplementation with Olive Oil or Fish Oil and Vascular Effects of Concentrated Ambient Particulate Matter Exposure in Human Volunteers.<h4>Background</h4>Exposure to ambient particulate matter (PM) induces endothelial dysfunction, a risk factor for cardiovascular disease. Olive oil (OO) and fish oil (FO) supplements have beneficial effects on endothelial function.<h4>Objective</h4>In this study we evaluated the potential efficacy of OO and FO in mitigating endothelial dysfunction and disruption of hemostasis caused by exposure to particulate matter (PM).<h4>Methods and results</h4>Forty-two participants (58 ± 1 years of age) received either 3 g/day of OO or FO, or no supplements (naive) for 4 weeks prior to undergoing 2-hr exposures to filtered air and concentrated ambient particulate matter (CAP; mean, 253 ± 16 μg/m3). Endothelial function was assessed by flow-mediated dilation (FMD) of the brachial artery preexposure, i2015-01-01T00:00:00Z2015 Nov2025-04-05T14:29:46.8Z2019-03-27T02:01:10ZS-EPMC46297412593319710.1289/ehp.1408988