{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["4(12)"],"submitter":["Zhu W"],"pubmed_abstract":["T and B cell receptor (TCR and BCR, respectively) Vβ or immunoglobulin heavy chain complementarity-determining region 3 sequencing allows monitoring of repertoire changes through recognition, clonal expansion, affinity maturation, and T or B cell activation in response to antigen. TCR and BCR repertoire analysis can advance understanding of antitumor immune responses in the tumor microenvironment. TCR and BCR repertoires of sorted CD4<sup>+</sup>, CD8<sup>+</sup> or CD19<sup>+</sup> cells in tumor, non-tumoral distant tissue (NT), and peripheral compartments (blood/draining lymph node [P]) from 47 non-small cell lung cancer (NSCLC) patients (age<sub>median</sub> = 68 y) were sequenced. The clonotype spectra were assessed among different tissues and correlated with clinical and immunologica"],"journal":["Oncoimmunology"],"pagination":["e1051922"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4635865"],"repository":["biostudies-literature"],"pubmed_title":["A high density of tertiary lymphoid structure B cells in lung tumors is associated with increased CD4<sup>+</sup> T cell receptor repertoire clonality."],"pmcid":["PMC4635865"],"pubmed_authors":["Hammond SA","Damotte D","Sebastian Y","Higgs BW","Valge-Archer V","Germain C","Liu Z","Yao Y","Devi P","Lehmann K","Dieu-Nosjean MC","Knockaert S","Validire P","Zhu W","Brohawn P"],"additional_accession":[]},"is_claimable":false,"name":"A high density of tertiary lymphoid structure B cells in lung tumors is associated with increased CD4<sup>+</sup> T cell receptor repertoire clonality.","description":"T and B cell receptor (TCR and BCR, respectively) Vβ or immunoglobulin heavy chain complementarity-determining region 3 sequencing allows monitoring of repertoire changes through recognition, clonal expansion, affinity maturation, and T or B cell activation in response to antigen. TCR and BCR repertoire analysis can advance understanding of antitumor immune responses in the tumor microenvironment. TCR and BCR repertoires of sorted CD4<sup>+</sup>, CD8<sup>+</sup> or CD19<sup>+</sup> cells in tumor, non-tumoral distant tissue (NT), and peripheral compartments (blood/draining lymph node [P]) from 47 non-small cell lung cancer (NSCLC) patients (age<sub>median</sub> = 68 y) were sequenced. The clonotype spectra were assessed among different tissues and correlated with clinical and immunologica","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Dec","modification":"2025-04-19T06:26:12.166Z","creation":"2019-03-27T02:01:29Z"},"accession":"S-EPMC4635865","cross_references":{"pubmed":["26587322"],"doi":["10.1080/2162402X.2015.1051922"]}}