biostudies-literatureUnknown4(12)Zhu WT and B cell receptor (TCR and BCR, respectively) Vβ or immunoglobulin heavy chain complementarity-determining region 3 sequencing allows monitoring of repertoire changes through recognition, clonal expansion, affinity maturation, and T or B cell activation in response to antigen. TCR and BCR repertoire analysis can advance understanding of antitumor immune responses in the tumor microenvironment. TCR and BCR repertoires of sorted CD4⁺, CD8⁺ or CD19⁺ cells in tumor, non-tumoral distant tissue (NT), and peripheral compartments (blood/draining lymph node [P]) from 47 non-small cell lung cancer (NSCLC) patients (age_median = 68 y) were sequenced. The clonotype spectra were assessed among different tissues and correlated with clinical and immunologicaOncoimmunologye1051922https://www.ebi.ac.uk/biostudies/studies/S-EPMC4635865biostudies-literatureA high density of tertiary lymphoid structure B cells in lung tumors is associated with increased CD4⁺ T cell receptor repertoire clonality.PMC4635865Hammond SADamotte DSebastian YHiggs BWValge-Archer VGermain CLiu ZYao YDevi PLehmann KDieu-Nosjean MCKnockaert SValidire PZhu WBrohawn PfalseA high density of tertiary lymphoid structure B cells in lung tumors is associated with increased CD4⁺ T cell receptor repertoire clonality.T and B cell receptor (TCR and BCR, respectively) Vβ or immunoglobulin heavy chain complementarity-determining region 3 sequencing allows monitoring of repertoire changes through recognition, clonal expansion, affinity maturation, and T or B cell activation in response to antigen. TCR and BCR repertoire analysis can advance understanding of antitumor immune responses in the tumor microenvironment. TCR and BCR repertoires of sorted CD4⁺, CD8⁺ or CD19⁺ cells in tumor, non-tumoral distant tissue (NT), and peripheral compartments (blood/draining lymph node [P]) from 47 non-small cell lung cancer (NSCLC) patients (age_median = 68 y) were sequenced. The clonotype spectra were assessed among different tissues and correlated with clinical and immunologica2015-01-01T00:00:00Z2015 Dec2025-04-19T06:26:12.166Z2019-03-27T02:01:29ZS-EPMC46358652658732210.1080/2162402X.2015.1051922