{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["25(12)"],"submitter":["Koch K"],"funding":["Wellcome Trust"],"pubmed_abstract":["Amyloid-β pathology (Aβ) and impaired cognition characterize Alzheimer's disease (AD); however, neural mechanisms that link Aβ-pathology with impaired cognition are incompletely understood. Large-scale intrinsic connectivity networks (ICNs) are potential candidates for this link: Aβ-pathology affects specific networks in early AD, these networks show disrupted connectivity, and they process specific cognitive functions impaired in AD, like memory or attention. We hypothesized that, in AD, regional changes of ICNs, which persist across rest- and cognitive task-states, might link Aβ-pathology with impaired cognition via impaired intrinsic connectivity. Pittsburgh compound B (PiB)-positron emission tomography reflecting in vivo Aβ-pathology, resting-state fMRI, task-fMRI, and cognitive testin"],"journal":["Cerebral cortex (New York, N.Y. : 1991)"],"pagination":["4678-88"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4635914"],"repository":["biostudies-literature"],"pubmed_title":["Disrupted Intrinsic Networks Link Amyloid-β Pathology and Impaired Cognition in Prodromal Alzheimer's Disease."],"pmcid":["PMC4635914"],"pubmed_authors":["Pasquini L","Grimmer T","Forster S","Manoliu A","Riedl V","Sorg C","Drzezga A","Koch K","Kurz A","Forstl H","Wohlschlager AM","Gottler J","Myers NE","Neitzel J"],"additional_accession":[]},"is_claimable":false,"name":"Disrupted Intrinsic Networks Link Amyloid-β Pathology and Impaired Cognition in Prodromal Alzheimer's Disease.","description":"Amyloid-β pathology (Aβ) and impaired cognition characterize Alzheimer's disease (AD); however, neural mechanisms that link Aβ-pathology with impaired cognition are incompletely understood. Large-scale intrinsic connectivity networks (ICNs) are potential candidates for this link: Aβ-pathology affects specific networks in early AD, these networks show disrupted connectivity, and they process specific cognitive functions impaired in AD, like memory or attention. We hypothesized that, in AD, regional changes of ICNs, which persist across rest- and cognitive task-states, might link Aβ-pathology with impaired cognition via impaired intrinsic connectivity. Pittsburgh compound B (PiB)-positron emission tomography reflecting in vivo Aβ-pathology, resting-state fMRI, task-fMRI, and cognitive testin","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Dec","modification":"2025-04-19T06:26:19.522Z","creation":"2025-04-19T06:26:19.522Z"},"accession":"S-EPMC4635914","cross_references":{"pubmed":["24996404"],"doi":["10.1093/cercor/bhu151"]}}