biostudies-literatureUddin LQNICHD NIH HHSNIMH NIH HHS4740-7https://www.ebi.ac.uk/biostudies/studies/S-EPMC4635916biostudies-literatureUnknown25(12)Autism spectrum disorders (ASDs) are characterized by social impairments alongside cognitive and behavioral inflexibility. While social deficits in ASDs have extensively been characterized, the neurobiological basis of inflexibility and its relation to core clinical symptoms of the disorder are unknown. We acquired functional neuroimaging data from 2 cohorts, each consisting of 17 children with ASDs and 17 age- and IQ-matched typically developing (TD) children, during stimulus-evoked brain states involving performance of social attention and numerical problem solving tasks, as well as during intrinsic, resting brain states. Effective connectivity between key nodes of the salience network, default mode network, and central executive network was used to obtain indices of functional organizatCerebral cortex (New York, N.Y. : 1991)Brain State Differentiation and Behavioral Inflexibility in Autism.PMC4635916R01 HD059205HD059205HD047520R01 HD047520R01 MH084164K01MH092288MH084164K01 MH092288Menon VPhillips JLynch CJAbrams DACheng KMOdriozola PBarth MEUddin LQFeinstein CSupekar KfalseBrain State Differentiation and Behavioral Inflexibility in Autism.Autism spectrum disorders (ASDs) are characterized by social impairments alongside cognitive and behavioral inflexibility. While social deficits in ASDs have extensively been characterized, the neurobiological basis of inflexibility and its relation to core clinical symptoms of the disorder are unknown. We acquired functional neuroimaging data from 2 cohorts, each consisting of 17 children with ASDs and 17 age- and IQ-matched typically developing (TD) children, during stimulus-evoked brain states involving performance of social attention and numerical problem solving tasks, as well as during intrinsic, resting brain states. Effective connectivity between key nodes of the salience network, default mode network, and central executive network was used to obtain indices of functional organizat2015-01-01T00:00:00Z2015 Dec2025-04-19T06:26:24.859Z2025-04-19T06:26:24.859ZS-EPMC46359162507372010.1093/cercor/bhu161