biostudies-literatureWanji SMedical Research CouncilWellcome Truste0004184https://www.ebi.ac.uk/biostudies/studies/S-EPMC4636288biostudies-literatureUnknown9(11)<h4>Background</h4>Immunochromatographic card test (ICT) is a tool to map the distribution of Wuchereria bancrofti. In areas highly endemic for loaisis in DRC and Cameroon, a relationship has been envisaged between high L. loa microfilaria (Mf) loads and ICT positivity. However, similar associations have not been demonstrated from other areas with contrasting levels of L. loa endemicity. This study investigated the cross-reactivity of ICT when mapping lymphatic filariasis (LF) in areas with contrasting endemicity levels of loiasis and mansonellosis in Cameroon.<h4>Methodology/principal findings</h4>A cross-sectional study to assess the prevalence and intensity of W. bancrofti, L. loa and M. perstans was carried out in 42 villages across three regions (East, North-west and South-west) of thPLoS neglected tropical diseasesCross-Reactivity of Filariais ICT Cards in Areas of Contrasting Endemicity of Loa loa and Mansonella perstans in Cameroon: Implications for Shrinking of the Lymphatic Filariasis Map in the Central African Region.PMC4636288100715G1001337Fombad FFNjouendou AJChounna Ndongmo PWFovennso BABockarie MEnyong PIFischer PUWanji SAmvongo-Adjia NKoudou BDatchoua-Poutcheu FRKengne-Ouafo JATayong DBfalseCross-Reactivity of Filariais ICT Cards in Areas of Contrasting Endemicity of Loa loa and Mansonella perstans in Cameroon: Implications for Shrinking of the Lymphatic Filariasis Map in the Central African Region.<h4>Background</h4>Immunochromatographic card test (ICT) is a tool to map the distribution of Wuchereria bancrofti. In areas highly endemic for loaisis in DRC and Cameroon, a relationship has been envisaged between high L. loa microfilaria (Mf) loads and ICT positivity. However, similar associations have not been demonstrated from other areas with contrasting levels of L. loa endemicity. This study investigated the cross-reactivity of ICT when mapping lymphatic filariasis (LF) in areas with contrasting endemicity levels of loiasis and mansonellosis in Cameroon.<h4>Methodology/principal findings</h4>A cross-sectional study to assess the prevalence and intensity of W. bancrofti, L. loa and M. perstans was carried out in 42 villages across three regions (East, North-west and South-west) of th2015-01-01T00:00:00Z2015 Nov2025-04-19T06:26:18.459Z2019-03-26T22:44:15ZS-EPMC46362882654404210.1371/journal.pntd.0004184