{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["McGorum BC"],"funding":["Darwin Trust of Edinburgh","Medical Research Council","Wellcome Trust","Biotechnology and Biological Sciences Research Council","The Equine Grass Sickness Fund"],"pagination":["3072-86"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4638047"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(11)"],"pubmed_abstract":["Equine grass sickness (EGS) is an acute, predominantly fatal, multiple system neuropathy of grazing horses with reported incidence rates of ∼2%. An apparently identical disease occurs in multiple species, including but not limited to cats, dogs, and rabbits. Although the precise etiology remains unclear, ultrastructural findings have suggested that the primary lesion lies in the glycoprotein biosynthetic pathway of specific neuronal populations. The goal of this study was therefore to identify the molecular processes underpinning neurodegeneration in EGS. Here, we use a bottom-up approach beginning with the application of modern proteomic tools to the analysis of cranial (superior) cervical ganglion (CCG, a consistently affected tissue) from EGS-affected patients and appropriate control ca"],"journal":["Molecular & cellular proteomics : MCP"],"pubmed_title":["Proteomic Profiling of Cranial (Superior) Cervical Ganglia Reveals Beta-Amyloid and Ubiquitin Proteasome System Perturbations in an Equine Multiple System Neuropathy."],"pmcid":["PMC4638047"],"funding_grant_id":["BBS/E/D/20251969","097945","MR/M010341/1","ISPG and DTP","1358987"],"pubmed_authors":["Pemberton A","Arnott DM","McGorum BC","Pirie RS","Llavero Hurtado M","Graham LC","Chen W","Keen JA","Wishart TM","Cumyn EM","Eaton SL","Lamont DJ"],"additional_accession":[]},"is_claimable":false,"name":"Proteomic Profiling of Cranial (Superior) Cervical Ganglia Reveals Beta-Amyloid and Ubiquitin Proteasome System Perturbations in an Equine Multiple System Neuropathy.","description":"Equine grass sickness (EGS) is an acute, predominantly fatal, multiple system neuropathy of grazing horses with reported incidence rates of ∼2%. An apparently identical disease occurs in multiple species, including but not limited to cats, dogs, and rabbits. Although the precise etiology remains unclear, ultrastructural findings have suggested that the primary lesion lies in the glycoprotein biosynthetic pathway of specific neuronal populations. The goal of this study was therefore to identify the molecular processes underpinning neurodegeneration in EGS. Here, we use a bottom-up approach beginning with the application of modern proteomic tools to the analysis of cranial (superior) cervical ganglion (CCG, a consistently affected tissue) from EGS-affected patients and appropriate control ca","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Nov","modification":"2026-05-01T21:02:26.803Z","creation":"2019-03-27T02:01:35Z"},"accession":"S-EPMC4638047","cross_references":{"pubmed":["26364976"],"doi":["10.1074/mcp.M115.054635"]}}