biostudies-literatureUnknown10(11)Stankiewicz AMPsychogenic stress contributes to the formation of brain pathology. Using gene expression microarrays, we analyzed the hippocampal transcriptome of mice subjected to acute and chronic social stress of different duration. The longest period of social stress altered the expression of the highest number of genes and most of the stress-induced changes in transcription were reversible after 5 days of rest. Chronic stress affected genes involved in the functioning of the vascular system (Alas2, Hbb-b1, Hba-a2, Hba-a1), injury response (Vwf, Mgp, Cfh, Fbln5, Col3a1, Ctgf) and inflammation (S100a8, S100a9, Ctla2a, Ctla2b, Lcn2, Lrg1, Rsad2, Isg20). The results suggest that stress may affect brain functions through the stress-induced dysfunction of the vascular system. An important issue raised in PloS onee0142195https://www.ebi.ac.uk/biostudies/studies/S-EPMC4640871biostudies-literatureThe Effect of Acute and Chronic Social Stress on the Hippocampal Transcriptome in Mice.PMC4640871Swiergiel AHJuszczak GRStankiewicz AMGoscik JMajewska AfalseThe Effect of Acute and Chronic Social Stress on the Hippocampal Transcriptome in Mice.Psychogenic stress contributes to the formation of brain pathology. Using gene expression microarrays, we analyzed the hippocampal transcriptome of mice subjected to acute and chronic social stress of different duration. The longest period of social stress altered the expression of the highest number of genes and most of the stress-induced changes in transcription were reversible after 5 days of rest. Chronic stress affected genes involved in the functioning of the vascular system (Alas2, Hbb-b1, Hba-a2, Hba-a1), injury response (Vwf, Mgp, Cfh, Fbln5, Col3a1, Ctgf) and inflammation (S100a8, S100a9, Ctla2a, Ctla2b, Lcn2, Lrg1, Rsad2, Isg20). The results suggest that stress may affect brain functions through the stress-induced dysfunction of the vascular system. An important issue raised in 2015-01-01T00:00:00Z20152026-04-07T20:28:58.97Z2019-03-26T23:28:11ZS-EPMC46408712655604610.1371/journal.pone.0142195