{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(11)"],"submitter":["Shen SM"],"pubmed_abstract":["Apoptosis-inducing factor (AIF) exerts dual roles on cell death and survival, but its substrates as a putative oxidoreductase and roles in tumorigenesis remain elusive. Here, we report that AIF physically interacts with and inhibits the oxidation of phosphatase and tensin homolog on chromosome ten (PTEN), a tumor suppressor susceptible for oxidation-mediated inactivation. More intriguingly, we also identify PTEN as a mitochondrial protein and the ectopic expression of mitochondrial targeting sequence-carrying PTEN almost completely inhibits Akt phosphorylation in PTEN-deficient cells. AIF knockdown causes oxidation-mediated inactivation of the lipid phosphatase activity of PTEN, with ensuing activation of Akt kinase, phosphorylation of the Akt substrate GSK-3β, and activation of β-catenin "],"journal":["EMBO reports"],"pagination":["1563-80"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4641507"],"repository":["biostudies-literature"],"pubmed_title":["AIF inhibits tumor metastasis by protecting PTEN from oxidation."],"pmcid":["PMC4641507"],"pubmed_authors":["Guo M","Xiong Z","Zhang FF","Shen SM","Zhao XY","Chen GQ","Yu Y"],"additional_accession":[]},"is_claimable":false,"name":"AIF inhibits tumor metastasis by protecting PTEN from oxidation.","description":"Apoptosis-inducing factor (AIF) exerts dual roles on cell death and survival, but its substrates as a putative oxidoreductase and roles in tumorigenesis remain elusive. Here, we report that AIF physically interacts with and inhibits the oxidation of phosphatase and tensin homolog on chromosome ten (PTEN), a tumor suppressor susceptible for oxidation-mediated inactivation. More intriguingly, we also identify PTEN as a mitochondrial protein and the ectopic expression of mitochondrial targeting sequence-carrying PTEN almost completely inhibits Akt phosphorylation in PTEN-deficient cells. AIF knockdown causes oxidation-mediated inactivation of the lipid phosphatase activity of PTEN, with ensuing activation of Akt kinase, phosphorylation of the Akt substrate GSK-3β, and activation of β-catenin ","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Nov","modification":"2026-05-05T15:15:31.317Z","creation":"2019-03-27T02:01:43Z"},"accession":"S-EPMC4641507","cross_references":{"pubmed":["26415504"],"doi":["10.15252/embr.201540536"]}}