biostudies-literatureWang LLNCI NIH HHS57-63https://www.ebi.ac.uk/biostudies/studies/S-EPMC4647535biostudies-literatureUnknown113(1)<h4>Background</h4>MYCN amplification with subsequent MYCN protein overexpression is a powerful indicator of poor prognosis of neuroblastoma patients. Little is known regarding the prognostic significance of the homologous MYC protein expression in neuroblastoma.<h4>Methods</h4>Immunostaining for MYCN and MYC protein was performed on 357 undifferentiated/poorly differentiated neuroblastomas. Results were analysed with other prognostic markers.<h4>Results</h4>Sixty-seven (19%) tumours were MYCN(+), 38 (11%) were MYC(+), and one(0.3%) had both proteins(+). MYCN(+) tumours and MYC(+) tumours were more likely diagnosed in children>18months with stage4-disease. MYCN(+) tumours were associated with amplified MYCN, Unfavourable Histology (UH), and High-MKI (Mitosis-Karyorrhexis Index). MYC(+) tumBritish journal of cancerAugmented expression of MYC and/or MYCN protein defines highly aggressive MYC-driven neuroblastoma: a Children's Oncology Group study.PMC4647535U10 CA098543R01CA127571P01 CA081403P01CA081403R01 CA127571U10 CA180886U10 CA180899U10CA98413U10CA98543U10 CA098413Maris JMAsgharzadeh SLook ATLondon WBIkegaki NNaranjo AHogarty MDPark JRCohn SLTeshiba RSeeger RCShimada HTang XXGastier-Foster JMWang LLfalseAugmented expression of MYC and/or MYCN protein defines highly aggressive MYC-driven neuroblastoma: a Children's Oncology Group study.<h4>Background</h4>MYCN amplification with subsequent MYCN protein overexpression is a powerful indicator of poor prognosis of neuroblastoma patients. Little is known regarding the prognostic significance of the homologous MYC protein expression in neuroblastoma.<h4>Methods</h4>Immunostaining for MYCN and MYC protein was performed on 357 undifferentiated/poorly differentiated neuroblastomas. Results were analysed with other prognostic markers.<h4>Results</h4>Sixty-seven (19%) tumours were MYCN(+), 38 (11%) were MYC(+), and one(0.3%) had both proteins(+). MYCN(+) tumours and MYC(+) tumours were more likely diagnosed in children>18months with stage4-disease. MYCN(+) tumours were associated with amplified MYCN, Unfavourable Histology (UH), and High-MKI (Mitosis-Karyorrhexis Index). MYC(+) tum2015-01-01T00:00:00Z2015 Jun2025-04-22T15:10:46.857Z2019-03-27T02:02:04ZS-EPMC46475352603570010.1038/bjc.2015.188