biostudies-literatureGuo YNCCIH NIH HHSMedical Research CouncilNCI NIH HHSWellcome Trust3336-44https://www.ebi.ac.uk/biostudies/studies/S-EPMC4648262biostudies-literatureUnknown192(7)Vitamin A deficiency leads to increased susceptibility to a spectrum of infectious diseases. The studies presented dissect the intrinsic role of each of the retinoic acid receptor (RAR) isoforms in the clonal expansion, differentiation, and survival of pathogen-specific CD8 T cells in vivo. The data show that RAR? is required for the expression of gut-homing receptors on CD8(+) T cells and survival of CD8(+) T cells in vitro. Furthermore, RAR? is essential for survival of CD8(+) T cells in vivo following Listeria monocytogenes infection. In contrast, RAR? deletion leads to modest deficiency in Ag-specific CD8(+) T cell expansion during infection. The defective survival of RAR?-deficient CD8(+) T cells leads to a deficiency in control of L. monocytogenes expansion in the spleen. To our knowledge, these are the first comparative studies of the role of RAR isoforms in CD8(+) T cell immunity.Journal of immunology (Baltimore, Md. : 1950)Dissecting the role of retinoic acid receptor isoforms in the CD8 response to infection.PMC4648262P30 CA023108091823R01AT005382R01 AT005382MR/J006742/1Lee YCZhang WUsherwood EGuo YNoelle RJBrown CfalseDissecting the role of retinoic acid receptor isoforms in the CD8 response to infection.Vitamin A deficiency leads to increased susceptibility to a spectrum of infectious diseases. The studies presented dissect the intrinsic role of each of the retinoic acid receptor (RAR) isoforms in the clonal expansion, differentiation, and survival of pathogen-specific CD8 T cells in vivo. The data show that RAR? is required for the expression of gut-homing receptors on CD8(+) T cells and survival of CD8(+) T cells in vitro. Furthermore, RAR? is essential for survival of CD8(+) T cells in vivo following Listeria monocytogenes infection. In contrast, RAR? deletion leads to modest deficiency in Ag-specific CD8(+) T cell expansion during infection. The defective survival of RAR?-deficient CD8(+) T cells leads to a deficiency in control of L. monocytogenes expansion in the spleen. To our knowledge, these are the first comparative studies of the role of RAR isoforms in CD8(+) T cell immunity.2014-01-01T00:00:00Z2014 Apr2020-10-29T10:43:21Z2019-03-27T02:02:06ZS-EPMC46482622461001210.4049/jimmunol.1301949