{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5"],"submitter":["Mombelli S"],"pubmed_abstract":["Pro-inflammatory IL-17 cytokines were initially described for their pathogenic role in chronic inflammatory diseases and subsequent accumulating evidence indicated their involvement in carcinogenesis. In the present study we report that IL-17A and IL-17E receptors subunits mRNA expressions are upregulated in breast cancers versus normal samples. IL-17E, which is undetectable in most normal breast tissues tested, seems more expressed in some tumors. Investigation of the molecular signaling following stimulation of human breast cancer cell lines with IL-17A and IL-17E showed that both cytokines induced the phosphorylation of c-RAF, ERK1/2 and p70 S6 Kinase were involved in the proliferation and survival of tumor cells. Accordingly, IL-17A and IL-17E promoted resistance to Docetaxel and faile"],"journal":["Scientific reports"],"pagination":["11874"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4648389"],"repository":["biostudies-literature"],"pubmed_title":["IL-17A and its homologs IL-25/IL-17E recruit the c-RAF/S6 kinase pathway and the generation of pro-oncogenic LMW-E in breast cancer cells."],"pmcid":["PMC4648389"],"pubmed_authors":["Eliaou JF","Bonnefoy N","Garbar C","Antonicelli F","Alberici G","Merrouche Y","Cochaud S","Laprevotte E","Bensussan A","Mombelli S","Bastid J","Giustiniani J"],"additional_accession":[]},"is_claimable":false,"name":"IL-17A and its homologs IL-25/IL-17E recruit the c-RAF/S6 kinase pathway and the generation of pro-oncogenic LMW-E in breast cancer cells.","description":"Pro-inflammatory IL-17 cytokines were initially described for their pathogenic role in chronic inflammatory diseases and subsequent accumulating evidence indicated their involvement in carcinogenesis. In the present study we report that IL-17A and IL-17E receptors subunits mRNA expressions are upregulated in breast cancers versus normal samples. IL-17E, which is undetectable in most normal breast tissues tested, seems more expressed in some tumors. Investigation of the molecular signaling following stimulation of human breast cancer cell lines with IL-17A and IL-17E showed that both cytokines induced the phosphorylation of c-RAF, ERK1/2 and p70 S6 Kinase were involved in the proliferation and survival of tumor cells. Accordingly, IL-17A and IL-17E promoted resistance to Docetaxel and faile","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jul","modification":"2026-05-05T10:44:05.85Z","creation":"2019-03-27T02:02:08Z"},"accession":"S-EPMC4648389","cross_references":{"pubmed":["26154409"],"doi":["10.1038/srep11874"]}}