{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Burns M"],"funding":["NIEHS NIH HHS","NCI NIH HHS","NIH HHS"],"pagination":["e0142630"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4648568"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(11)"],"pubmed_abstract":["Iron deficiency anemia (IDA) affects > 500 million people worldwide, and is linked to impaired cognitive development and function in children. Helicobacter pylori, a class 1 carcinogen, infects about half of the world's population, thus creating a high likelihood of overlapping risk. This study determined the effect of H. pylori infection on iron homeostasis in INS-GAS mice. Two replicates of INS-GAS/FVB male mice (n = 9-12/group) were dosed with H. pylori (Hp) strain SS1 or sham dosed at 6-9 weeks of age, and were necropsied at 27-29 weeks of age. Hematologic and serum iron parameters were evaluated, as was gene expression in gastric and brain tissues. Serum ferritin was lower in Hp SS1-infected mice than uninfected mice (p < 0.0001). Infected mice had a lower red blood cell count (p<0.00"],"journal":["PloS one"],"pubmed_title":["Helicobacter pylori Infection Induces Anemia, Depletes Serum Iron Storage, and Alters Local Iron-Related and Adult Brain Gene Expression in Male INS-GAS Mice."],"pmcid":["PMC4648568"],"funding_grant_id":["R01 CA067529","P01 CA028842","R01 CA093405","R01CA093405","P30 ES002109","P30ES0022109","T32 OD010978","P01CA028842-23"],"pubmed_authors":["Muthupalani S","Ennis K","Georgieff M","Fox JG","Ge Z","Cunningham C","Burns M","Wang TC","Bakthavatchalu V"],"additional_accession":[]},"is_claimable":false,"name":"Helicobacter pylori Infection Induces Anemia, Depletes Serum Iron Storage, and Alters Local Iron-Related and Adult Brain Gene Expression in Male INS-GAS Mice.","description":"Iron deficiency anemia (IDA) affects > 500 million people worldwide, and is linked to impaired cognitive development and function in children. Helicobacter pylori, a class 1 carcinogen, infects about half of the world's population, thus creating a high likelihood of overlapping risk. This study determined the effect of H. pylori infection on iron homeostasis in INS-GAS mice. Two replicates of INS-GAS/FVB male mice (n = 9-12/group) were dosed with H. pylori (Hp) strain SS1 or sham dosed at 6-9 weeks of age, and were necropsied at 27-29 weeks of age. Hematologic and serum iron parameters were evaluated, as was gene expression in gastric and brain tissues. Serum ferritin was lower in Hp SS1-infected mice than uninfected mice (p < 0.0001). Infected mice had a lower red blood cell count (p<0.00","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015","modification":"2025-05-29T22:27:56.449Z","creation":"2025-05-29T22:27:56.449Z"},"accession":"S-EPMC4648568","cross_references":{"pubmed":["26575645"],"doi":["10.1371/journal.pone.0142630"]}}