{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5"],"submitter":["Makino A"],"pubmed_abstract":["Borna disease virus (BDV) has a non-segmented, negative-stranded RNA genome and causes persistent infection in many animal species. Previous study has shown that the activation of the IκB kinase (IKK)/NF-κB pathway is reduced by BDV infection even in cells expressing constitutively active mutant IKK. This result suggests that BDV directly interferes with the IKK/NF-κB pathway. To elucidate the mechanism for the inhibition of NF-κB activation by BDV infection, we evaluated the cross-talk between BDV infection and the NF-κB pathway. Using Multiple EM for Motif Elicitation analysis, we found that the nucleoproteins of BDV (BDV-N) and NF-κB1 share a common ankyrin-like motif. When THP1-CD14 cells were pre-treated with the identified peptide, NF-κB activation by Toll-like receptor ligands was s"],"journal":["Scientific reports"],"pagination":["8696"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4649702"],"repository":["biostudies-literature"],"pubmed_title":["Borna disease virus possesses an NF-ĸB inhibitory sequence in the nucleoprotein gene."],"pmcid":["PMC4649702"],"pubmed_authors":["Tomonaga K","Fujino K","Parrish NF","Makino A","Honda T"],"additional_accession":[]},"is_claimable":false,"name":"Borna disease virus possesses an NF-ĸB inhibitory sequence in the nucleoprotein gene.","description":"Borna disease virus (BDV) has a non-segmented, negative-stranded RNA genome and causes persistent infection in many animal species. Previous study has shown that the activation of the IκB kinase (IKK)/NF-κB pathway is reduced by BDV infection even in cells expressing constitutively active mutant IKK. This result suggests that BDV directly interferes with the IKK/NF-κB pathway. To elucidate the mechanism for the inhibition of NF-κB activation by BDV infection, we evaluated the cross-talk between BDV infection and the NF-κB pathway. Using Multiple EM for Motif Elicitation analysis, we found that the nucleoproteins of BDV (BDV-N) and NF-κB1 share a common ankyrin-like motif. When THP1-CD14 cells were pre-treated with the identified peptide, NF-κB activation by Toll-like receptor ligands was s","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Mar","modification":"2026-05-05T11:38:20.019Z","creation":"2019-03-27T02:02:12Z"},"accession":"S-EPMC4649702","cross_references":{"pubmed":["25733193"],"doi":["10.1038/srep08696"]}}