{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huergo LF"],"funding":["Biotechnology and Biological Sciences Research Council"],"pagination":["419-35"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4651028"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["79(4)"],"pubmed_abstract":["The metabolite 2-oxoglutarate (also known as α-ketoglutarate, 2-ketoglutaric acid, or oxoglutaric acid) lies at the intersection between the carbon and nitrogen metabolic pathways. This compound is a key intermediate of one of the most fundamental biochemical pathways in carbon metabolism, the tricarboxylic acid (TCA) cycle. In addition, 2-oxoglutarate also acts as the major carbon skeleton for nitrogen-assimilatory reactions. Experimental data support the conclusion that intracellular levels of 2-oxoglutarate fluctuate according to nitrogen and carbon availability. This review summarizes how nature has capitalized on the ability of 2-oxoglutarate to reflect cellular nutritional status through evolution of a variety of 2-oxoglutarate-sensing regulatory proteins. The number of metabolic pat"],"journal":["Microbiology and molecular biology reviews : MMBR"],"pubmed_title":["The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite."],"pmcid":["PMC4651028"],"funding_grant_id":["BBS/E/J/00000016"],"pubmed_authors":["Dixon R","Huergo LF"],"additional_accession":[]},"is_claimable":false,"name":"The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite.","description":"The metabolite 2-oxoglutarate (also known as α-ketoglutarate, 2-ketoglutaric acid, or oxoglutaric acid) lies at the intersection between the carbon and nitrogen metabolic pathways. This compound is a key intermediate of one of the most fundamental biochemical pathways in carbon metabolism, the tricarboxylic acid (TCA) cycle. In addition, 2-oxoglutarate also acts as the major carbon skeleton for nitrogen-assimilatory reactions. Experimental data support the conclusion that intracellular levels of 2-oxoglutarate fluctuate according to nitrogen and carbon availability. This review summarizes how nature has capitalized on the ability of 2-oxoglutarate to reflect cellular nutritional status through evolution of a variety of 2-oxoglutarate-sensing regulatory proteins. The number of metabolic pat","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Dec","modification":"2025-04-18T18:28:20.739Z","creation":"2019-03-27T02:02:19Z"},"accession":"S-EPMC4651028","cross_references":{"pubmed":["26424716"],"doi":["10.1128/mmbr.00038-15","10.1128/MMBR.00038-15"]}}