biostudies-literatureMunroe MENIAID NIH HHSNIAMS NIH HHSNIGMS NIH HHS396-409https://www.ebi.ac.uk/biostudies/studies/S-EPMC4653095biostudies-literatureUnknown35(5)Systemic lupus erythematosus is a heterogeneous autoimmune disease marked by the presence of pathogenic autoantibodies, immune dysregulation, and chronic inflammation that may lead to increased morbidity and early mortality from end-organ damage. More than half of all systemic lupus erythematosus patients will develop lupus nephritis. Genetic-association studies have identified more than 50 polymorphisms that contribute to lupus nephritis pathogenesis, including genetic variants associated with altered programmed cell death and defective immune clearance of programmed cell death debris. These variants may support the generation of autoantibody-containing immune complexes that contribute to lupus nephritis. Genetic variants associated with lupus nephritis also affect the initial phase of inSeminars in nephrologyGenetics of Lupus Nephritis: Clinical Implications.PMC4653095U54 GM104938U54GM104938U19AI082714P30GM103510P30 AR053483U19 AI082714P30AR053483P30 GM103510U01AI101934U01 AI101934James JAMunroe MEfalseGenetics of Lupus Nephritis: Clinical Implications.Systemic lupus erythematosus is a heterogeneous autoimmune disease marked by the presence of pathogenic autoantibodies, immune dysregulation, and chronic inflammation that may lead to increased morbidity and early mortality from end-organ damage. More than half of all systemic lupus erythematosus patients will develop lupus nephritis. Genetic-association studies have identified more than 50 polymorphisms that contribute to lupus nephritis pathogenesis, including genetic variants associated with altered programmed cell death and defective immune clearance of programmed cell death debris. These variants may support the generation of autoantibody-containing immune complexes that contribute to lupus nephritis. Genetic variants associated with lupus nephritis also affect the initial phase of in2015-01-01T00:00:00Z2015 Sep2025-04-22T14:24:05.062Z2019-03-27T02:02:25ZS-EPMC46530952657354310.1016/j.semnephrol.2015.08.002