{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(11)"],"submitter":["Davin A"],"pubmed_abstract":["<h4>Background</h4>Depression is common in the elderly. The role of genetic and environmental factors in modulating depressive symptoms is not clear.<h4>Methods</h4>We evaluated the influence of serotonin transporter gene polymorphisms and recent adverse life events on depressive symptoms in an elderly Italian population. We used data from \"InveCe.Ab\", a population-based study of 1321 subjects aged 70-74 years. We used the 15-item Geriatric Depression Scale (GDS) to assess depressive symptoms-a GDS score ≥5 points (GDS≥5) indicated the presence of clinically relevant symptoms-and performed 5-HTTLPR and rs25531 genotyping to obtain the triallelic polymorphism of the serotonin transporter. We used the Geriatric Adverse Life Events Scale to measure adverse life events, and logistic regression"],"journal":["PloS one"],"pagination":["e0143395"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4658113"],"repository":["biostudies-literature"],"pubmed_title":["Influence of Serotonin Transporter Gene Polymorphisms and Adverse Life Events on Depressive Symptoms in the Elderly: A Population-Based Study."],"pmcid":["PMC4658113"],"pubmed_authors":["Davin A","Vaccaro R","Monti MC","Villani S","Guaita A","Abbondanza S","Gnesi M","Polito L"],"additional_accession":[]},"is_claimable":false,"name":"Influence of Serotonin Transporter Gene Polymorphisms and Adverse Life Events on Depressive Symptoms in the Elderly: A Population-Based Study.","description":"<h4>Background</h4>Depression is common in the elderly. The role of genetic and environmental factors in modulating depressive symptoms is not clear.<h4>Methods</h4>We evaluated the influence of serotonin transporter gene polymorphisms and recent adverse life events on depressive symptoms in an elderly Italian population. We used data from \"InveCe.Ab\", a population-based study of 1321 subjects aged 70-74 years. We used the 15-item Geriatric Depression Scale (GDS) to assess depressive symptoms-a GDS score ≥5 points (GDS≥5) indicated the presence of clinically relevant symptoms-and performed 5-HTTLPR and rs25531 genotyping to obtain the triallelic polymorphism of the serotonin transporter. We used the Geriatric Adverse Life Events Scale to measure adverse life events, and logistic regression","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015","modification":"2026-05-05T15:59:02.264Z","creation":"2019-03-26T22:56:21Z"},"accession":"S-EPMC4658113","cross_references":{"pubmed":["26598970"],"doi":["10.1371/journal.pone.0143395"]}}