biostudies-literatureUnknown10(11)Davin A<h4>Background</h4>Depression is common in the elderly. The role of genetic and environmental factors in modulating depressive symptoms is not clear.<h4>Methods</h4>We evaluated the influence of serotonin transporter gene polymorphisms and recent adverse life events on depressive symptoms in an elderly Italian population. We used data from "InveCe.Ab", a population-based study of 1321 subjects aged 70-74 years. We used the 15-item Geriatric Depression Scale (GDS) to assess depressive symptoms-a GDS score ≥5 points (GDS≥5) indicated the presence of clinically relevant symptoms-and performed 5-HTTLPR and rs25531 genotyping to obtain the triallelic polymorphism of the serotonin transporter. We used the Geriatric Adverse Life Events Scale to measure adverse life events, and logistic regressionPloS onee0143395https://www.ebi.ac.uk/biostudies/studies/S-EPMC4658113biostudies-literatureInfluence of Serotonin Transporter Gene Polymorphisms and Adverse Life Events on Depressive Symptoms in the Elderly: A Population-Based Study.PMC4658113Davin AVaccaro RMonti MCVillani SGuaita AAbbondanza SGnesi MPolito LfalseInfluence of Serotonin Transporter Gene Polymorphisms and Adverse Life Events on Depressive Symptoms in the Elderly: A Population-Based Study.<h4>Background</h4>Depression is common in the elderly. The role of genetic and environmental factors in modulating depressive symptoms is not clear.<h4>Methods</h4>We evaluated the influence of serotonin transporter gene polymorphisms and recent adverse life events on depressive symptoms in an elderly Italian population. We used data from "InveCe.Ab", a population-based study of 1321 subjects aged 70-74 years. We used the 15-item Geriatric Depression Scale (GDS) to assess depressive symptoms-a GDS score ≥5 points (GDS≥5) indicated the presence of clinically relevant symptoms-and performed 5-HTTLPR and rs25531 genotyping to obtain the triallelic polymorphism of the serotonin transporter. We used the Geriatric Adverse Life Events Scale to measure adverse life events, and logistic regression2015-01-01T00:00:00Z20152026-05-05T15:59:02.264Z2019-03-26T22:56:21ZS-EPMC46581132659897010.1371/journal.pone.0143395