biostudies-literatureUnknown12(11)Watanabe MThis study aimed to investigate the effects of particulate matter (PM) on pulmonary function in schoolchildren, as well as the relationships of these effects with interleukin-8. Morning peak expiratory flow (PEF) was measured daily in 399 children during April-May 2012, and in 384 of these children during March-May 2013. PEF's association with the daily levels of suspended particulate matter (SPM) and PM < 2.5 mm (PM2.5) was estimated using a linear mixed model. Interleukin-8 promoter activity was assessed in THP-G8 cells stimulated by fallen PM collected at Tottori University Hospital during four periods (two in 2012 and two in 2013). An increase of 14.0 mg/m³ in SPM led to PEF changes of -2.16 L/min in 2012 and -0.81 L/min in 2013, respectively. An increment of 10.7 mg/m³ in PM2.5 was asInternational journal of environmental research and public health14229-43https://www.ebi.ac.uk/biostudies/studies/S-EPMC4661643biostudies-literatureVariation in the Effect of Particulate Matter on Pulmonary Function in Schoolchildren in Western Japan and Its Relation with Interleukin-8.PMC4661643Saito RKimura YNoma HKurai JKitano HWatanabe MShimizu EAiba SSano HOshimura MfalseVariation in the Effect of Particulate Matter on Pulmonary Function in Schoolchildren in Western Japan and Its Relation with Interleukin-8.This study aimed to investigate the effects of particulate matter (PM) on pulmonary function in schoolchildren, as well as the relationships of these effects with interleukin-8. Morning peak expiratory flow (PEF) was measured daily in 399 children during April-May 2012, and in 384 of these children during March-May 2013. PEF's association with the daily levels of suspended particulate matter (SPM) and PM < 2.5 mm (PM2.5) was estimated using a linear mixed model. Interleukin-8 promoter activity was assessed in THP-G8 cells stimulated by fallen PM collected at Tottori University Hospital during four periods (two in 2012 and two in 2013). An increase of 14.0 mg/m³ in SPM led to PEF changes of -2.16 L/min in 2012 and -0.81 L/min in 2013, respectively. An increment of 10.7 mg/m³ in PM2.5 was as2015-01-01T00:00:00Z2015 Nov2025-04-19T03:01:54.919Z2019-03-27T02:02:50ZS-EPMC46616432656927210.3390/ijerph121114229