{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Forini F"],"funding":["Tuscany Region Research Grant"],"pagination":["26687-705"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4661832"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(11)"],"pubmed_abstract":["Mitochondria are major determinants of cell fate in ischemia/reperfusion injury (IR) and common effectors of cardio-protective strategies in cardiac ischemic disease. Thyroid hormone homeostasis critically affects mitochondrial function and energy production. Since a low T3 state (LT3S) is frequently observed in the post infarction setting, the study was aimed to investigate the relationship between 72 h post IR T3 levels and both the cardiac function and the mitochondrial proteome in a rat model of IR. The low T3 group exhibits the most compromised cardiac performance along with the worst mitochondrial activity. Accordingly, our results show a different remodeling of the mitochondrial proteome in the presence or absence of a LT3S, with alterations in groups of proteins that play a key rol"],"journal":["International journal of molecular sciences"],"pubmed_title":["Low T3 State Is Correlated with Cardiac Mitochondrial Impairments after Ischemia Reperfusion Injury: Evidence from a Proteomic Approach."],"pmcid":["PMC4661832"],"funding_grant_id":["DGR 1157/2011"],"pubmed_authors":["Nicolini G","Iervasi G","Forini F","Citti L","Cecchettini A","Rocchiccioli S","Ucciferri N","Kusmic C"],"additional_accession":[]},"is_claimable":false,"name":"Low T3 State Is Correlated with Cardiac Mitochondrial Impairments after Ischemia Reperfusion Injury: Evidence from a Proteomic Approach.","description":"Mitochondria are major determinants of cell fate in ischemia/reperfusion injury (IR) and common effectors of cardio-protective strategies in cardiac ischemic disease. Thyroid hormone homeostasis critically affects mitochondrial function and energy production. Since a low T3 state (LT3S) is frequently observed in the post infarction setting, the study was aimed to investigate the relationship between 72 h post IR T3 levels and both the cardiac function and the mitochondrial proteome in a rat model of IR. The low T3 group exhibits the most compromised cardiac performance along with the worst mitochondrial activity. Accordingly, our results show a different remodeling of the mitochondrial proteome in the presence or absence of a LT3S, with alterations in groups of proteins that play a key rol","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Nov","modification":"2026-05-05T07:33:57.463Z","creation":"2025-05-18T11:59:50.293Z"},"accession":"S-EPMC4661832","cross_references":{"pubmed":["26561807"],"doi":["10.3390/ijms161125973"]}}