{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vizoso M"],"funding":["European Research Council"],"pagination":["1453-63"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4662832"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["36(12)"],"pubmed_abstract":["Epigenetic changes through altered DNA methylation have been implicated in critical aspects of tumor progression, and have been extensively studied in a variety of cancer types. In contrast, our current knowledge of the aberrant genomic DNA methylation in tumor-associated fibroblasts (TAFs) or other stromal cells that act as critical coconspirators of tumor progression is very scarce. To address this gap of knowledge, we conducted genome-wide DNA methylation profiling on lung TAFs and paired control fibroblasts (CFs) from non-small cell lung cancer patients using the HumanMethylation450 microarray. We found widespread DNA hypomethylation concomitant with focal gain of DNA methylation in TAFs compared to CFs. The aberrant DNA methylation landscape of TAFs had a global impact on gene express"],"journal":["Carcinogenesis"],"pubmed_title":["Aberrant DNA methylation in non-small cell lung cancer-associated fibroblasts."],"pmcid":["PMC4662832"],"funding_grant_id":["616480"],"pubmed_authors":["Ramirez J","Carmona FJ","Gabasa M","Vizoso M","Reguart N","Esteller M","Rigat-Brugarolas LG","Moran S","Trepat X","Alcaraz J","Gomez A","Lugo R","Vidal E","Puig M","Velasquez A","Perera A","Labernadie A","Maqueda M"],"additional_accession":[]},"is_claimable":false,"name":"Aberrant DNA methylation in non-small cell lung cancer-associated fibroblasts.","description":"Epigenetic changes through altered DNA methylation have been implicated in critical aspects of tumor progression, and have been extensively studied in a variety of cancer types. In contrast, our current knowledge of the aberrant genomic DNA methylation in tumor-associated fibroblasts (TAFs) or other stromal cells that act as critical coconspirators of tumor progression is very scarce. To address this gap of knowledge, we conducted genome-wide DNA methylation profiling on lung TAFs and paired control fibroblasts (CFs) from non-small cell lung cancer patients using the HumanMethylation450 microarray. We found widespread DNA hypomethylation concomitant with focal gain of DNA methylation in TAFs compared to CFs. The aberrant DNA methylation landscape of TAFs had a global impact on gene express","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Dec","modification":"2026-05-05T07:10:02.46Z","creation":"2019-03-27T02:02:54Z"},"accession":"S-EPMC4662832","cross_references":{"pubmed":["26449251"],"doi":["10.1093/carcin/bgv146"]}}