biostudies-literatureGorczyca DNINDS NIH HHS1033-44https://www.ebi.ac.uk/biostudies/studies/S-EPMC4664082biostudies-literatureUnknown27(5)Targeted membrane addition is a hallmark of many cellular functions. In the nervous system, modification of synaptic membrane size has a major impact on synaptic function. However, because of the complex shape of neurons and the need to target membrane addition to very small and polarized synaptic compartments, this process is poorly understood. Here, we show that Gtaxin (GTX), a Drosophila t-SNARE (target-soluble N-ethylmaleimide-sensitive factor attachment protein receptor), is required for expansion of postsynaptic membranes during new synapse formation. Mutations in gtx lead to drastic reductions in postsynaptic membrane surface, whereas gtx upregulation results in the formation of complex membrane structures at ectopic sites. Postsynaptic GTX activity depends on its direct interactionThe Journal of neuroscience : the official journal of the Society for NeurosciencePostsynaptic membrane addition depends on the Discs-Large-interacting t-SNARE Gtaxin.PMC4664082R01 NS042629R01 NS030072Ashley JGundelfinger EGorczyca DSpeese SThomas UGherbesi NGramates LSBudnik VfalsePostsynaptic membrane addition depends on the Discs-Large-interacting t-SNARE Gtaxin.Targeted membrane addition is a hallmark of many cellular functions. In the nervous system, modification of synaptic membrane size has a major impact on synaptic function. However, because of the complex shape of neurons and the need to target membrane addition to very small and polarized synaptic compartments, this process is poorly understood. Here, we show that Gtaxin (GTX), a Drosophila t-SNARE (target-soluble N-ethylmaleimide-sensitive factor attachment protein receptor), is required for expansion of postsynaptic membranes during new synapse formation. Mutations in gtx lead to drastic reductions in postsynaptic membrane surface, whereas gtx upregulation results in the formation of complex membrane structures at ectopic sites. Postsynaptic GTX activity depends on its direct interaction2007-01-01T00:00:00Z2007 Jan2025-04-04T20:26:09.889Z2019-06-06T15:09:35ZS-EPMC46640821726755710.1523/JNEUROSCI.3160-06.200710.1523/jneurosci.3160-06.2007