{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pezzulo G"],"funding":["American Heart Association","Human Frontier Science Program","G Harold and Leila Y. Mathers Foundation","National Institutes of Health","NIAMS NIH HHS","Emergent Behaviors of Integrated Cellular Systems"],"pagination":["1487-517"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4667987"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(12)"],"pubmed_abstract":["A major goal of regenerative medicine and bioengineering is the regeneration of complex organs, such as limbs, and the capability to create artificial constructs (so-called biobots) with defined morphologies and robust self-repair capabilities. Developmental biology presents remarkable examples of systems that self-assemble and regenerate complex structures toward their correct shape despite significant perturbations. A fundamental challenge is to translate progress in molecular genetics into control of large-scale organismal anatomy, and the field is still searching for an appropriate theoretical paradigm for facilitating control of pattern homeostasis. However, computational neuroscience provides many examples in which cell networks - brains - store memories (e.g., of geometric configura"],"journal":["Integrative biology : quantitative biosciences from nano to macro"],"pubmed_title":["Re-membering the body: applications of computational neuroscience to the top-down control of regeneration of limbs and other complex organs."],"pmcid":["PMC4667987"],"funding_grant_id":["14IRG18570000","AR055993","CBET-0939511","RGY0088/2014","R01 AR055993"],"pubmed_authors":["Levin M","Pezzulo G"],"additional_accession":[]},"is_claimable":false,"name":"Re-membering the body: applications of computational neuroscience to the top-down control of regeneration of limbs and other complex organs.","description":"A major goal of regenerative medicine and bioengineering is the regeneration of complex organs, such as limbs, and the capability to create artificial constructs (so-called biobots) with defined morphologies and robust self-repair capabilities. Developmental biology presents remarkable examples of systems that self-assemble and regenerate complex structures toward their correct shape despite significant perturbations. A fundamental challenge is to translate progress in molecular genetics into control of large-scale organismal anatomy, and the field is still searching for an appropriate theoretical paradigm for facilitating control of pattern homeostasis. However, computational neuroscience provides many examples in which cell networks - brains - store memories (e.g., of geometric configura","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Dec","modification":"2025-04-04T14:06:12.24Z","creation":"2019-03-27T02:04:31Z"},"accession":"S-EPMC4667987","cross_references":{"pubmed":["26571046"],"doi":["10.1039/c5ib00221d"]}}