biostudies-literaturePezzulo GAmerican Heart AssociationHuman Frontier Science ProgramG Harold and Leila Y. Mathers FoundationNational Institutes of HealthNIAMS NIH HHSEmergent Behaviors of Integrated Cellular Systems1487-517https://www.ebi.ac.uk/biostudies/studies/S-EPMC4667987biostudies-literatureUnknown7(12)A major goal of regenerative medicine and bioengineering is the regeneration of complex organs, such as limbs, and the capability to create artificial constructs (so-called biobots) with defined morphologies and robust self-repair capabilities. Developmental biology presents remarkable examples of systems that self-assemble and regenerate complex structures toward their correct shape despite significant perturbations. A fundamental challenge is to translate progress in molecular genetics into control of large-scale organismal anatomy, and the field is still searching for an appropriate theoretical paradigm for facilitating control of pattern homeostasis. However, computational neuroscience provides many examples in which cell networks - brains - store memories (e.g., of geometric configuraIntegrative biology : quantitative biosciences from nano to macroRe-membering the body: applications of computational neuroscience to the top-down control of regeneration of limbs and other complex organs.PMC466798714IRG18570000AR055993CBET-0939511RGY0088/2014R01 AR055993Levin MPezzulo GfalseRe-membering the body: applications of computational neuroscience to the top-down control of regeneration of limbs and other complex organs.A major goal of regenerative medicine and bioengineering is the regeneration of complex organs, such as limbs, and the capability to create artificial constructs (so-called biobots) with defined morphologies and robust self-repair capabilities. Developmental biology presents remarkable examples of systems that self-assemble and regenerate complex structures toward their correct shape despite significant perturbations. A fundamental challenge is to translate progress in molecular genetics into control of large-scale organismal anatomy, and the field is still searching for an appropriate theoretical paradigm for facilitating control of pattern homeostasis. However, computational neuroscience provides many examples in which cell networks - brains - store memories (e.g., of geometric configura2015-01-01T00:00:00Z2015 Dec2025-04-04T14:06:12.24Z2019-03-27T02:04:31ZS-EPMC46679872657104610.1039/c5ib00221d