{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ivancevic A"],"funding":["NCI NIH HHS","NIGMS NIH HHS"],"pagination":["eado1218"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC466953"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(29)"],"pubmed_abstract":["Cancer cells exhibit rewired transcriptional regulatory networks that promote tumor growth and survival. However, the mechanisms underlying the formation of these pathological networks remain poorly understood. Through a pan-cancer epigenomic analysis, we found that primate-specific endogenous retroviruses (ERVs) are a rich source of enhancers displaying cancer-specific activity. In colorectal cancer and other epithelial tumors, oncogenic MAPK/AP1 signaling drives the activation of enhancers derived from the primate-specific ERV family LTR10. Functional studies in colorectal cancer cells revealed that LTR10 elements regulate tumor-specific expression of multiple genes associated with tumorigenesis, such as <i>ATG12</i> and <i>XRCC4</i>. Within the human population, individual LTR10 element"],"journal":["Science advances"],"pubmed_title":["Endogenous retroviruses mediate transcriptional rewiring in response to oncogenic signaling in colorectal cancer."],"pmcid":["PMC466953"],"funding_grant_id":["R37 CA261987","T32 GM142607","R35 GM128822"],"pubmed_authors":["Joyner OM","Bagby SM","Nguyen LL","Chuong EB","Ivancevic A","Simpson DM","Bitler BG","Pitts TM"],"additional_accession":[]},"is_claimable":false,"name":"Endogenous retroviruses mediate transcriptional rewiring in response to oncogenic signaling in colorectal cancer.","description":"Cancer cells exhibit rewired transcriptional regulatory networks that promote tumor growth and survival. However, the mechanisms underlying the formation of these pathological networks remain poorly understood. Through a pan-cancer epigenomic analysis, we found that primate-specific endogenous retroviruses (ERVs) are a rich source of enhancers displaying cancer-specific activity. In colorectal cancer and other epithelial tumors, oncogenic MAPK/AP1 signaling drives the activation of enhancers derived from the primate-specific ERV family LTR10. Functional studies in colorectal cancer cells revealed that LTR10 elements regulate tumor-specific expression of multiple genes associated with tumorigenesis, such as <i>ATG12</i> and <i>XRCC4</i>. Within the human population, individual LTR10 element","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-04-30T00:08:50.071Z","creation":"2025-04-04T15:03:05.435Z"},"accession":"S-EPMC466953","cross_references":{"pubmed":["39018396"],"doi":["10.1126/sciadv.ado1218"]}}