{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(12)"],"submitter":["Tosetto A"],"pubmed_abstract":["<h4>Background</h4>Center-specific TTR (c-TTR) is a measure reporting the mean patient TTR within an anticoagulation clinic describing the quality of anticoagulant monitoring offered by that clinic. c-TTR has a considerable between-center variation, but its determinants are poorly understood.<h4>Objectives</h4>We aimed at evaluating which clinical, procedural or laboratory factors could be associated with c-TTR variability in a multicenter, observational cross-sectional study over a five-year period.<h4>Patients/methods</h4>Data from 832,204 individual patients followed for VKA therapy in 292 Centers affiliated with the Italian Federation of Anticoagulation Clinics (FCSA) were analyzed. c-TTR was computed based on the TTR of patients followed at each Center, and a mixed linear regression m"],"journal":["PloS one"],"pagination":["e0144314"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4670074"],"repository":["biostudies-literature"],"pubmed_title":["Center-Related Determinants of VKA Anticoagulation Quality: A Prospective, Multicenter Evaluation."],"pmcid":["PMC4670074"],"pubmed_authors":["Lucia LR","Giordana O","Capalbo SF","Piovella F","Rende A","Alberto T","Abbruzzese L","Marongiu F","Insana A","Peres E","Alberto N","Bianchi P","Galani I","Caccia R","Vasselli C","Ninivaggi G","Giuseppina S","Macino E","Di Pierro MN","Insegnante V","Veneranda I","Liva","Serino ML","Giuseppina M","Tani","Silvestri L","Vincenzo S","Ciola P","Gabriele A","Chiarugi P","Tosetto A","Ciabatta C","Pedrini S","Antonia G","Gilda N","Fidone E","Marco","Capuano G","Enrico P","Catello M","Confalonieri A","D'Agostino M","Maria C","Cattaneo M","Giuseppe R","Feola G","Savino E","Giuseppe L","Aurelio M","Nello Z","Luigia M","Santucci E","Gavino P","Santoro R","Sbarbaro FG","Gristina T","Rosichini F","Di Prospero L","Simonetta SM","Pizzoferrato A","De Cristofaro R","Olimpieri OM","Giancarlo M","Amati L","Daniele G","Vittorio P","Roberto C","Roberto Q","Giovanni P","Nicoletta E","Francesca V","Cesare M","Contu MA","Cesari L","Collina G","Agape V","Marrocco F","Giovanni B","Giovanni A","Bilotta MC","Luigi R","Molinatti M","Mazzone A","Martini G","Gabriella M","Michela C","Rolla MC","Rosaria LM","Sabatini M","Rizzo MA","Domenico P","Alberti G","Carrato P","Maria CA","Aurora C","Manotti C","Tonini V","Vincenza R","Enrica A","Milillo P","Agatino VM","Grazia G","Valentino T","Consorte R","Ferrari M","Pernigotti A","Raffaele R","Di Gregorio P","Moia M","Iacobelli AR","Spilotros G","Pini F","Giacomo L","Bonfanti C","Assunta O","Albarosa R","Angelo D","Marchetti A","Bolognese E","Mori M","Rita T","Umberto R","Carbone A","Umberto V","Italian Federation of Anticoagulation Clinics (FCSA) clinical quality study group","Sonnante AM","Luciano S","Eugenio B","Rosa MM","Lamioni M","Contino L","Francesco R","Feliciangeli M","Francesco P","Parente D","Bersano C","Ruocco L","Itala C","Schiavoni M","Gesualdo U","Nadia C","Marco C","Alessandro P","Roberta R","Gaidano G","Angelo S","Marinella C"],"additional_accession":[]},"is_claimable":false,"name":"Center-Related Determinants of VKA Anticoagulation Quality: A Prospective, Multicenter Evaluation.","description":"<h4>Background</h4>Center-specific TTR (c-TTR) is a measure reporting the mean patient TTR within an anticoagulation clinic describing the quality of anticoagulant monitoring offered by that clinic. c-TTR has a considerable between-center variation, but its determinants are poorly understood.<h4>Objectives</h4>We aimed at evaluating which clinical, procedural or laboratory factors could be associated with c-TTR variability in a multicenter, observational cross-sectional study over a five-year period.<h4>Patients/methods</h4>Data from 832,204 individual patients followed for VKA therapy in 292 Centers affiliated with the Italian Federation of Anticoagulation Clinics (FCSA) were analyzed. c-TTR was computed based on the TTR of patients followed at each Center, and a mixed linear regression m","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015","modification":"2025-04-22T07:16:35.481Z","creation":"2019-03-26T22:56:28Z"},"accession":"S-EPMC4670074","cross_references":{"pubmed":["26636337"],"doi":["10.1371/journal.pone.0144314"]}}