biostudies-literatureUnknown10(12)Tosetto A<h4>Background</h4>Center-specific TTR (c-TTR) is a measure reporting the mean patient TTR within an anticoagulation clinic describing the quality of anticoagulant monitoring offered by that clinic. c-TTR has a considerable between-center variation, but its determinants are poorly understood.<h4>Objectives</h4>We aimed at evaluating which clinical, procedural or laboratory factors could be associated with c-TTR variability in a multicenter, observational cross-sectional study over a five-year period.<h4>Patients/methods</h4>Data from 832,204 individual patients followed for VKA therapy in 292 Centers affiliated with the Italian Federation of Anticoagulation Clinics (FCSA) were analyzed. c-TTR was computed based on the TTR of patients followed at each Center, and a mixed linear regression mPloS onee0144314https://www.ebi.ac.uk/biostudies/studies/S-EPMC4670074biostudies-literatureCenter-Related Determinants of VKA Anticoagulation Quality: A Prospective, Multicenter Evaluation.PMC4670074Lucia LRGiordana OCapalbo SFPiovella FRende AAlberto TAbbruzzese LMarongiu FInsana APeres EAlberto NBianchi PGalani ICaccia RVasselli CNinivaggi GGiuseppina SMacino EDi Pierro MNInsegnante VVeneranda ILivaSerino MLGiuseppina MTaniSilvestri LVincenzo SCiola PGabriele AChiarugi PTosetto ACiabatta CPedrini SAntonia GGilda NFidone EMarcoCapuano GEnrico PCatello MConfalonieri AD'Agostino MMaria CCattaneo MGiuseppe RFeola GSavino EGiuseppe LAurelio MNello ZLuigia MSantucci EGavino PSantoro RSbarbaro FGGristina TRosichini FDi Prospero LSimonetta SMPizzoferrato ADe Cristofaro ROlimpieri OMGiancarlo MAmati LDaniele GVittorio PRoberto CRoberto QGiovanni PNicoletta EFrancesca VCesare MContu MACesari LCollina GAgape VMarrocco FGiovanni BGiovanni ABilotta MCLuigi RMolinatti MMazzone AMartini GGabriella MMichela CRolla MCRosaria LMSabatini MRizzo MADomenico PAlberti GCarrato PMaria CAAurora CManotti CTonini VVincenza REnrica AMilillo PAgatino VMGrazia GValentino TConsorte RFerrari MPernigotti ARaffaele RDi Gregorio PMoia MIacobelli ARSpilotros GPini FGiacomo LBonfanti CAssunta OAlbarosa RAngelo DMarchetti ABolognese EMori MRita TUmberto RCarbone AUmberto VItalian Federation of Anticoagulation Clinics (FCSA) clinical quality study groupSonnante AMLuciano SEugenio BRosa MMLamioni MContino LFrancesco RFeliciangeli MFrancesco PParente DBersano CRuocco LItala CSchiavoni MGesualdo UNadia CMarco CAlessandro PRoberta RGaidano GAngelo SMarinella CfalseCenter-Related Determinants of VKA Anticoagulation Quality: A Prospective, Multicenter Evaluation.<h4>Background</h4>Center-specific TTR (c-TTR) is a measure reporting the mean patient TTR within an anticoagulation clinic describing the quality of anticoagulant monitoring offered by that clinic. c-TTR has a considerable between-center variation, but its determinants are poorly understood.<h4>Objectives</h4>We aimed at evaluating which clinical, procedural or laboratory factors could be associated with c-TTR variability in a multicenter, observational cross-sectional study over a five-year period.<h4>Patients/methods</h4>Data from 832,204 individual patients followed for VKA therapy in 292 Centers affiliated with the Italian Federation of Anticoagulation Clinics (FCSA) were analyzed. c-TTR was computed based on the TTR of patients followed at each Center, and a mixed linear regression m2015-01-01T00:00:00Z20152025-04-22T07:16:35.481Z2019-03-26T22:56:28ZS-EPMC46700742663633710.1371/journal.pone.0144314