{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wilson RA"],"funding":["Wellcome Trust"],"pagination":["e0004272"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4671649"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(12)"],"pubmed_abstract":["<h4>Background</h4>The schistosome esophagus is divided into anterior and posterior compartments, each surrounded by a dense cluster of gland cell bodies, the source of distinct secretory vesicles discharged into the lumen to initiate the processing of ingested blood. Erythrocytes are lysed in the lumen, leucocytes are tethered and killed and platelets are eliminated. We know little about the proteins secreted from the two glands that mediate these biological processes.<h4>Methodology/principal findings</h4>We have used subtractive RNA-Seq to characterise the complement of genes that are differentially expressed in a head preparation, compared to matched tissues from worm tails. The expression site of representative highlighted genes was then validated using whole munt in situ hybridisatio"],"journal":["PLoS neglected tropical diseases"],"pubmed_title":["The Schistosome Esophagus Is a 'Hotspot' for Microexon and Lysosomal Hydrolase Gene Expression: Implications for Blood Processing."],"pmcid":["PMC4671649"],"funding_grant_id":["105264"],"pubmed_authors":["DeMarco R","James S","Farias LP","Ashton PD","Castro Borges W","Leite LC","Vitoriano-Souza J","Li XH","Wilson RA","MacDonald S","Neves LX"],"additional_accession":[]},"is_claimable":false,"name":"The Schistosome Esophagus Is a 'Hotspot' for Microexon and Lysosomal Hydrolase Gene Expression: Implications for Blood Processing.","description":"<h4>Background</h4>The schistosome esophagus is divided into anterior and posterior compartments, each surrounded by a dense cluster of gland cell bodies, the source of distinct secretory vesicles discharged into the lumen to initiate the processing of ingested blood. Erythrocytes are lysed in the lumen, leucocytes are tethered and killed and platelets are eliminated. We know little about the proteins secreted from the two glands that mediate these biological processes.<h4>Methodology/principal findings</h4>We have used subtractive RNA-Seq to characterise the complement of genes that are differentially expressed in a head preparation, compared to matched tissues from worm tails. The expression site of representative highlighted genes was then validated using whole munt in situ hybridisatio","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Dec","modification":"2026-05-05T19:25:45.993Z","creation":"2026-04-07T21:53:19.564Z"},"accession":"S-EPMC4671649","cross_references":{"pubmed":["26642053"],"doi":["10.1371/journal.pntd.0004272"]}}