{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fuchs BB"],"funding":["Brown-Brazil Initiative","NIDA NIH HHS","National Institutes of Health (US)","Astellas Pharma US (US)","Natural Science Grant of China"],"pagination":["17-25"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4676791"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["181(1-2)"],"pubmed_abstract":["The echinocandin family of drugs is well characterized for antifungal function that inhibits β-D-glucan synthesis. The aim of this work was to study whether micafungin, a member of the echinocandin family, elicits additional activities that prime the host's immune response. We found that in a Galleria mellonella model, prophylactic treatment with micafungin extended the life of Staphylococcus aureus-infected larvae (a pathogen to which the drug demonstrates no direct antimicrobial activity) compared to insects that did not receive micafungin (P < 0.05). The inhibition of pathogens in the G. mellonella infection model was characterized by a 2.43-fold increase in hemocyte density, compared to larvae inoculated with PBS. In a murine model where animals were provided micafungin prophylaxis 3 d"],"journal":["Mycopathologia"],"pubmed_title":["Micafungin Elicits an Immunomodulatory Effect in Galleria mellonella and Mice."],"pmcid":["PMC4676791"],"funding_grant_id":["T32 DA013911","T-32DA013911","81102480"],"pubmed_authors":["Li G","Li Y","Mylonakis E","Li D","Fuchs BB","Hendricks G","Rajamuthiah R","Johnston T"],"additional_accession":[]},"is_claimable":false,"name":"Micafungin Elicits an Immunomodulatory Effect in Galleria mellonella and Mice.","description":"The echinocandin family of drugs is well characterized for antifungal function that inhibits β-D-glucan synthesis. The aim of this work was to study whether micafungin, a member of the echinocandin family, elicits additional activities that prime the host's immune response. We found that in a Galleria mellonella model, prophylactic treatment with micafungin extended the life of Staphylococcus aureus-infected larvae (a pathogen to which the drug demonstrates no direct antimicrobial activity) compared to insects that did not receive micafungin (P < 0.05). The inhibition of pathogens in the G. mellonella infection model was characterized by a 2.43-fold increase in hemocyte density, compared to larvae inoculated with PBS. In a murine model where animals were provided micafungin prophylaxis 3 d","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Feb","modification":"2025-04-21T19:27:46.244Z","creation":"2019-03-27T02:05:01Z"},"accession":"S-EPMC4676791","cross_references":{"pubmed":["26384671"],"doi":["10.1007/s11046-015-9940-z"]}}