biostudies-literatureFuchs BBBrown-Brazil InitiativeNIDA NIH HHSNational Institutes of Health (US)Astellas Pharma US (US)Natural Science Grant of China17-25https://www.ebi.ac.uk/biostudies/studies/S-EPMC4676791biostudies-literatureUnknown181(1-2)The echinocandin family of drugs is well characterized for antifungal function that inhibits β-D-glucan synthesis. The aim of this work was to study whether micafungin, a member of the echinocandin family, elicits additional activities that prime the host's immune response. We found that in a Galleria mellonella model, prophylactic treatment with micafungin extended the life of Staphylococcus aureus-infected larvae (a pathogen to which the drug demonstrates no direct antimicrobial activity) compared to insects that did not receive micafungin (P < 0.05). The inhibition of pathogens in the G. mellonella infection model was characterized by a 2.43-fold increase in hemocyte density, compared to larvae inoculated with PBS. In a murine model where animals were provided micafungin prophylaxis 3 dMycopathologiaMicafungin Elicits an Immunomodulatory Effect in Galleria mellonella and Mice.PMC4676791T32 DA013911T-32DA01391181102480Li GLi YMylonakis ELi DFuchs BBHendricks GRajamuthiah RJohnston TfalseMicafungin Elicits an Immunomodulatory Effect in Galleria mellonella and Mice.The echinocandin family of drugs is well characterized for antifungal function that inhibits β-D-glucan synthesis. The aim of this work was to study whether micafungin, a member of the echinocandin family, elicits additional activities that prime the host's immune response. We found that in a Galleria mellonella model, prophylactic treatment with micafungin extended the life of Staphylococcus aureus-infected larvae (a pathogen to which the drug demonstrates no direct antimicrobial activity) compared to insects that did not receive micafungin (P < 0.05). The inhibition of pathogens in the G. mellonella infection model was characterized by a 2.43-fold increase in hemocyte density, compared to larvae inoculated with PBS. In a murine model where animals were provided micafungin prophylaxis 3 d2016-01-01T00:00:00Z2016 Feb2025-04-21T19:27:46.244Z2019-03-27T02:05:01ZS-EPMC46767912638467110.1007/s11046-015-9940-z