{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5"],"submitter":["Cosentino A"],"pubmed_abstract":["Micromixers are the key component that allow lab-on-a-chip and micro total analysis systems to reach the correct level of mixing for any given process. This paper proposes a novel, simple, passive micromixer design characterized by a planar accordion-shape geometry. The geometrical characteristics of the presented design were analyzed numerically in the range of 0.01 < Re < 100 based on the micromixer performance. The performance of the most efficient design was experimentally investigated by means of fluorescence microscopy for a range of low diffusion coefficients, 10(-12) < D < 10(-11) m(2)/s. The micromixer structure was fabricated in a simple single-step process using maskless lithography and soft lithography. The experimental results showed a very good agreement with the predicted numerical results. This micromixer design including a single serpentine unit (1-SERP) displayed an efficiency higher than 90% (mixing length = 6.4 mm) creating a pressure drop of about 500 Pa at Re = 0.1 and 60 kPa at Re = 10. A mixing efficiency of almost 100% was readily reached when three serpentine units were included (3-SERP). Finally, the potential diagnostic value of the presented microdevice was validated experimentally for Red Blood Cell (RBC) lysis."],"journal":["Scientific reports"],"pagination":["17876"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4677335"],"repository":["biostudies-literature"],"pubmed_title":["An efficient planar accordion-shaped micromixer: from biochemical mixing to biological application."],"pmcid":["PMC4677335"],"pubmed_authors":["Cosentino A","Vergara P","Vecchione R","Causa F","Netti PA","Madadi H"],"additional_accession":[]},"is_claimable":false,"name":"An efficient planar accordion-shaped micromixer: from biochemical mixing to biological application.","description":"Micromixers are the key component that allow lab-on-a-chip and micro total analysis systems to reach the correct level of mixing for any given process. This paper proposes a novel, simple, passive micromixer design characterized by a planar accordion-shape geometry. The geometrical characteristics of the presented design were analyzed numerically in the range of 0.01 < Re < 100 based on the micromixer performance. The performance of the most efficient design was experimentally investigated by means of fluorescence microscopy for a range of low diffusion coefficients, 10(-12) < D < 10(-11) m(2)/s. The micromixer structure was fabricated in a simple single-step process using maskless lithography and soft lithography. The experimental results showed a very good agreement with the predicted numerical results. This micromixer design including a single serpentine unit (1-SERP) displayed an efficiency higher than 90% (mixing length = 6.4 mm) creating a pressure drop of about 500 Pa at Re = 0.1 and 60 kPa at Re = 10. A mixing efficiency of almost 100% was readily reached when three serpentine units were included (3-SERP). Finally, the potential diagnostic value of the presented microdevice was validated experimentally for Red Blood Cell (RBC) lysis.","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Dec","modification":"2024-11-09T15:56:14.616Z","creation":"2019-03-27T02:05:03Z"},"accession":"S-EPMC4677335","cross_references":{"pubmed":["26658848"],"doi":["10.1038/srep17876"]}}