{"database":"biostudies-literature","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":50,"searchCount":0},"additional":{"omics_type":["Unknown"],"volume":["8(10)"],"submitter":["Shi J"],"pubmed_abstract":["Gastric cancer (GC) is one of the most common malignancies and one of the major causes of cancer-related deaths worldwide. In the present study, we investigated the association between miR-449a rs112310158 SNP and GC risk. Our findings revealed that a variant GG genotype increased the risk of occurrence of GC compared to a wild type AA genotype (OR = 2.542, 95% CI: 1.304-4.954, P = 0.005). Specifically, the G allele reduced the risk of occurrence of cervical cancer in women compared to the A allele (OR = 1.279, 95% CI: 1.012-1.617, P = 0.043). In conclusion, our findings suggest that miR-449a rs112310158 is a genetic risk factor for GC."],"journal":["International journal of clinical and experimental pathology"],"pagination":["13387-92"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4680490"],"repository":["biostudies-literature"],"pubmed_title":["Hsa-miR-449a genetic variant is associated with risk of gastric cancer in a Chinese population."],"pmcid":["PMC4680490"],"pubmed_authors":["Liu Y","Liu J","Shi J","Zhou J"],"view_count":["50"],"additional_accession":[]},"is_claimable":false,"name":"Hsa-miR-449a genetic variant is associated with risk of gastric cancer in a Chinese population.","description":"Gastric cancer (GC) is one of the most common malignancies and one of the major causes of cancer-related deaths worldwide. In the present study, we investigated the association between miR-449a rs112310158 SNP and GC risk. Our findings revealed that a variant GG genotype increased the risk of occurrence of GC compared to a wild type AA genotype (OR = 2.542, 95% CI: 1.304-4.954, P = 0.005). Specifically, the G allele reduced the risk of occurrence of cervical cancer in women compared to the A allele (OR = 1.279, 95% CI: 1.012-1.617, P = 0.043). In conclusion, our findings suggest that miR-449a rs112310158 is a genetic risk factor for GC.","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015","modification":"2021-02-20T02:28:43Z","creation":"2019-06-06T15:12:22Z"},"accession":"S-EPMC4680490","cross_references":{"pubmed":["26722545"]}}