{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5"],"submitter":["Mi Z"],"pubmed_abstract":["Human BST-2 inhibits HIV-1 replication by tethering nascent virions to the cell surface. HIV-1 codes Vpu that counteracts BST-2 by down-regulating this restriction factor from the cell surface. This important function makes Vpu a potential therapeutic target. Yet, no agents have been reported to block Vpu from antagonizing BST-2. In this study, we report a small molecule compound IMB-LA that abrogates the function of Vpu and thereby strongly suppresses HIV-1 replication by sensitizing the virus to BST-2 restriction. Further studies revealed that IMB-LA specifically inhibits Vpu-mediated degradation of BST-2 and restores the expression of BST-2 at the cell surface. Although IMB-LA does not prevent Vpu from interacting with BST-2 or β-TrCP2-containing ubiquitin E3 ligase, sorting of BST-2 in"],"journal":["Scientific reports"],"pagination":["18499"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4680884"],"repository":["biostudies-literature"],"pubmed_title":["A small molecule compound IMB-LA inhibits HIV-1 infection by preventing viral Vpu from antagonizing the host restriction factor BST-2."],"pmcid":["PMC4680884"],"pubmed_authors":["Shan G","Cen S","Ma L","Zhang L","Ding J","Zhang Q","Yu H","Liang C","Li X","Mi Z","Liu Z","Wei T","Guo F","Zhao J","Zhou J"],"additional_accession":[]},"is_claimable":false,"name":"A small molecule compound IMB-LA inhibits HIV-1 infection by preventing viral Vpu from antagonizing the host restriction factor BST-2.","description":"Human BST-2 inhibits HIV-1 replication by tethering nascent virions to the cell surface. HIV-1 codes Vpu that counteracts BST-2 by down-regulating this restriction factor from the cell surface. This important function makes Vpu a potential therapeutic target. Yet, no agents have been reported to block Vpu from antagonizing BST-2. In this study, we report a small molecule compound IMB-LA that abrogates the function of Vpu and thereby strongly suppresses HIV-1 replication by sensitizing the virus to BST-2 restriction. Further studies revealed that IMB-LA specifically inhibits Vpu-mediated degradation of BST-2 and restores the expression of BST-2 at the cell surface. Although IMB-LA does not prevent Vpu from interacting with BST-2 or β-TrCP2-containing ubiquitin E3 ligase, sorting of BST-2 in","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Dec","modification":"2026-05-05T15:59:17.831Z","creation":"2019-03-27T02:05:14Z"},"accession":"S-EPMC4680884","cross_references":{"pubmed":["26669976"],"doi":["10.1038/srep18499"]}}