{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Marsden KC"],"funding":["NEI NIH HHS","NIMH NIH HHS","NINDS NIH HHS"],"pagination":["1733-40"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4680997"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(9)"],"pubmed_abstract":["Exposure to repetitive startling stimuli induces habitation, a simple form of learning. Despite its simplicity, the precise cellular mechanisms by which repeated stimulation converts a robust behavioral response to behavioral indifference are unclear. Here, we use head-restrained zebrafish larvae to monitor subcellular Ca(2+) dynamics in Mauthner neurons, the startle command neurons, during startle habituation in vivo. Using the Ca(2+) reporter GCaMP6s, we find that the amplitude of Ca(2+) signals in the lateral dendrite of the Mauthner neuron determines startle probability and that depression of this dendritic activity rather than downstream inhibition mediates glycine and N-methyl-D-aspartate (NMDA)-receptor-dependent short-term habituation. Combined, our results suggest a model for habituation learning in which increased inhibitory drive from feedforward inhibitory neurons combined with decreased excitatory input from auditory afferents decreases dendritic and Mauthner neuron excitability."],"journal":["Cell reports"],"pubmed_title":["In Vivo Ca(2+) Imaging Reveals that Decreased Dendritic Excitability Drives Startle Habituation."],"pmcid":["PMC4680997"],"funding_grant_id":["R01 MH075691","R01 MH092257","R01 EY024861","F32-NS-077815","MH092257","MH103545","EY024861","R03 MH102680","F32 NS077815","R21 MH103545"],"pubmed_authors":["Marsden KC","Granato M"],"additional_accession":[]},"is_claimable":false,"name":"In Vivo Ca(2+) Imaging Reveals that Decreased Dendritic Excitability Drives Startle Habituation.","description":"Exposure to repetitive startling stimuli induces habitation, a simple form of learning. Despite its simplicity, the precise cellular mechanisms by which repeated stimulation converts a robust behavioral response to behavioral indifference are unclear. Here, we use head-restrained zebrafish larvae to monitor subcellular Ca(2+) dynamics in Mauthner neurons, the startle command neurons, during startle habituation in vivo. Using the Ca(2+) reporter GCaMP6s, we find that the amplitude of Ca(2+) signals in the lateral dendrite of the Mauthner neuron determines startle probability and that depression of this dendritic activity rather than downstream inhibition mediates glycine and N-methyl-D-aspartate (NMDA)-receptor-dependent short-term habituation. Combined, our results suggest a model for habituation learning in which increased inhibitory drive from feedforward inhibitory neurons combined with decreased excitatory input from auditory afferents decreases dendritic and Mauthner neuron excitability.","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Dec","modification":"2025-04-19T08:22:28.734Z","creation":"2019-03-27T02:05:15Z"},"accession":"S-EPMC4680997","cross_references":{"pubmed":["26655893"],"doi":["10.1016/j.celrep.2015.10.060"]}}