biostudies-literatureOgura YNIA NIH HHSNIAMS NIH HHS10123https://www.ebi.ac.uk/biostudies/studies/S-EPMC4682113biostudies-literatureUnknown6Satellite cells are resident adult stem cells that are required for regeneration of skeletal muscle. However, signalling mechanisms that regulate satellite cell function are less understood. Here we demonstrate that transforming growth factor-β-activated kinase 1 (TAK1) is important in satellite stem cell homeostasis and function. Inactivation of TAK1 in satellite cells inhibits muscle regeneration in adult mice. TAK1 is essential for satellite cell proliferation and its inactivation causes precocious differentiation. Moreover, TAK1-deficient satellite cells exhibit increased oxidative stress and undergo spontaneous cell death, primarily through necroptosis. TAK1 is required for the activation of NF-κB and JNK in satellite cells. Forced activation of NF-κB improves survival and proliferatiNature communicationsTAK1 modulates satellite stem cell homeostasis and skeletal muscle repair.PMC4682113AR068313AG029623R01 AG029623R01 AR068313AR059810R01 AR059810Ogura YHindi SMSato SAkira SKumar AXiong GfalseTAK1 modulates satellite stem cell homeostasis and skeletal muscle repair.Satellite cells are resident adult stem cells that are required for regeneration of skeletal muscle. However, signalling mechanisms that regulate satellite cell function are less understood. Here we demonstrate that transforming growth factor-β-activated kinase 1 (TAK1) is important in satellite stem cell homeostasis and function. Inactivation of TAK1 in satellite cells inhibits muscle regeneration in adult mice. TAK1 is essential for satellite cell proliferation and its inactivation causes precocious differentiation. Moreover, TAK1-deficient satellite cells exhibit increased oxidative stress and undergo spontaneous cell death, primarily through necroptosis. TAK1 is required for the activation of NF-κB and JNK in satellite cells. Forced activation of NF-κB improves survival and proliferati2015-01-01T00:00:00Z2015 Dec2026-05-05T07:28:14.901Z2019-03-27T02:05:20ZS-EPMC46821132664852910.1038/ncomms10123